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Article

Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration

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Wills Eye Hospital, 840 Walnut St., Philadelphia, PA 19107, USA
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Ophthalmic Consultants of Boston, 50 Staniford St., Ste. 600, Boston, MA 02114, USA
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Pepose Vision Institute, 1815 Clarkson Road, Chesterfield, MO 63124, USA
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The Retina Group of Washington, 110 Irving St NW, Washington, DC 20010, USA
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Virginia Eye Institute, 6946 Forest Ave Suite 100, Richmond, VA 23230, USA
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Tennessee Retina, 345 23rd Avenue North, Suite 350, Nashville, TN 37203, USA
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Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, i-32, Cleveland, OH 44106, USA
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Notal Vision, 7717 Coppermine Dr., Manassas, VA 20109, USA
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Elman Retina, 7671 Quarterfield Rd #100, Glen Burnie, MD 21061, USA
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Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv 6209105, Israel
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The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
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Retina Vitreous Associates of Florida, 4344 Central Ave, St. Petersburg, FL 33711, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Laurent Kodjikian
J. Clin. Med. 2021, 10(7), 1355; https://doi.org/10.3390/jcm10071355
Received: 9 February 2021 / Revised: 16 March 2021 / Accepted: 19 March 2021 / Published: 25 March 2021
The real-world performance of a home telemonitoring strategy (ForeseeHome AMD Monitoring System®, Notal Vision, Inc.,Manassas VA, USA) was evaluated and compared to the device arm of the AREDS2-HOME study among patients with intermediate AMD (iAMD) who converted to neovascular AMD (nAMD). All patients with confirmed conversion to nAMD who used the home monitoring system from 10/2009 through 9/2018 were identified by Notal Vision Diagnostic Clinic’s medical records. Selected outcome variables were evaluated, including visual acuity (VA) at baseline and at conversion, and change in visual acuity (VA) from baseline to time of conversion. In total, 8991 patients performed 3,200,999 tests at a frequency of 5.6 ± 3.2 times/week. The 306 eyes that converted from iAMD to nAMD over the study period (a 2.7% annual rate) were included in the analyses. There was a median (interquartile range) change of −3.0 (0.0–(−10.0)) letters among converted eyes, 81% [95% confidence interval (72–88%)] maintained a VA ≥ 20/40 at the time of conversion, while 69% of the conversion detections were triggered by system alerts. The real-world performance of an at-home testing strategy was similar to that reported for the device arm of the AREDS2-HOME study. The home telemonitoring system can markedly increase early detection of conversion to nAMD. View Full-Text
Keywords: ForeseeHome AMD Monitoring System®; neovascular age-related macular degeneration; AREDS2-HOME study ForeseeHome AMD Monitoring System®; neovascular age-related macular degeneration; AREDS2-HOME study
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MDPI and ACS Style

Ho, A.C.; Heier, J.S.; Holekamp, N.M.; Garfinkel, R.A.; Ladd, B.; Awh, C.C.; Singh, R.P.; Sanborn, G.E.; Jacobs, J.H.; Elman, M.J.; Loewenstein, A.; Eichenbaum, D.A. Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration. J. Clin. Med. 2021, 10, 1355. https://doi.org/10.3390/jcm10071355

AMA Style

Ho AC, Heier JS, Holekamp NM, Garfinkel RA, Ladd B, Awh CC, Singh RP, Sanborn GE, Jacobs JH, Elman MJ, Loewenstein A, Eichenbaum DA. Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration. Journal of Clinical Medicine. 2021; 10(7):1355. https://doi.org/10.3390/jcm10071355

Chicago/Turabian Style

Ho, Allen C., Jeffrey S. Heier, Nancy M. Holekamp, Richard A. Garfinkel, Byron Ladd, Carl C. Awh, Rishi P. Singh, George E. Sanborn, Jennifer H. Jacobs, Michael J. Elman, Anat Loewenstein, and David A. Eichenbaum 2021. "Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration" Journal of Clinical Medicine 10, no. 7: 1355. https://doi.org/10.3390/jcm10071355

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