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Article

Midterm Results of Microhook ab Interno Trabeculotomy in Initial 560 Eyes with Glaucoma

1
Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan
2
Division of Ophthalmology, Matsue Red Cross Hospital, Matsue 690-8506, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Sentaro Kusuhara
J. Clin. Med. 2021, 10(4), 814; https://doi.org/10.3390/jcm10040814
Received: 24 January 2021 / Revised: 11 February 2021 / Accepted: 12 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue Novel Therapeutics in Glaucoma Management)
All the 560 glaucomatous eyes of 375 Japanese subjects (181 men, 194 women; mean age ± standard deviation, 76.0 ± 13.2 years) who underwent microhook ab interno trabeculotomy (µLOT) alone (159 eyes, 28%) or combined µLOT and cataract surgery (401 eyes, 72%) performed by one surgeon at Matsue Red Cross Hospital between May 2015 and March 2018 to control intraocular pressure (IOP) were retrospectively assessed. Preoperative and postoperative IOPs, numbers of antiglaucoma medications, the logarithm of the minimum angle of resolution visual acuity (logMAR VA), anterior chamber (AC) flare, visual field mean deviation (MD), and corneal endothelial cell density (CECD) were compared up to 36 months. Surgical complications and required interventions were described. The duration of the follow-up was 405 ± 327 (range, 2–1326) days. The mean preoperative IOP (20.2 ± 7.0 mmHg) and number of antiglaucoma medications (2.8 ± 1.1) decreased to 13.9 ± 4.5 mmHg (31% reduction, p < 0.0001) and 2.5 ± 1.0 (11% reduction, p < 0.0001), respectively, at the final visit. After combined surgery, compared with preoperatively, the final VA improved 0.11 logMAR (p < 0.0001), AC flare increased 4.5 photon counts/msec (p = 0.0011), MD improved 0.6 decibel (p < 0.0001), and the CECD decreased 6% (p < 0.0001). Layered hyphema (172 eyes, 31%) and hyphema washout (26 eyes, 5%) were the most common postoperative complication and intervention, respectively. At the final visit, 379 (69%) eyes achieved successful IOP control of ≤18 mmHg and ≥20% IOP reduction, and 349 (64%) eyes achieved successful IOP control of ≤15 mmHg and ≥20% IOP reduction. Older age, steroid-induced glaucoma, developmental glaucoma, and the absence of postoperative complications were associated with lower final IOP; exfoliation glaucoma, other types of glaucoma, and higher preoperative IOP were associated with higher final IOP. µLOT has a significant IOP-lowering potential in patients with glaucoma, and improves visual function when combined with cataract surgery. View Full-Text
Keywords: minimally invasive glaucoma surgery (MIGS); Tanito microhook (TMH); surgical efficacy; surgical complication minimally invasive glaucoma surgery (MIGS); Tanito microhook (TMH); surgical efficacy; surgical complication
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MDPI and ACS Style

Tanito, M.; Sugihara, K.; Tsutsui, A.; Hara, K.; Manabe, K.; Matsuoka, Y. Midterm Results of Microhook ab Interno Trabeculotomy in Initial 560 Eyes with Glaucoma. J. Clin. Med. 2021, 10, 814. https://doi.org/10.3390/jcm10040814

AMA Style

Tanito M, Sugihara K, Tsutsui A, Hara K, Manabe K, Matsuoka Y. Midterm Results of Microhook ab Interno Trabeculotomy in Initial 560 Eyes with Glaucoma. Journal of Clinical Medicine. 2021; 10(4):814. https://doi.org/10.3390/jcm10040814

Chicago/Turabian Style

Tanito, Masaki, Kazunobu Sugihara, Aika Tsutsui, Katsunori Hara, Kaoru Manabe, and Yotaro Matsuoka. 2021. "Midterm Results of Microhook ab Interno Trabeculotomy in Initial 560 Eyes with Glaucoma" Journal of Clinical Medicine 10, no. 4: 814. https://doi.org/10.3390/jcm10040814

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