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Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management
Review

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

1
Namur Thrombosis and Hemostasis Center (NTHC), CHU UCL Namur, Université Catholique de Louvain, 5530 Yvoir, Belgium
2
Section of Clinical Biochemistry, University of Verona, 37134 Verona, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Hugo ten Cate
J. Clin. Med. 2021, 10(4), 594; https://doi.org/10.3390/jcm10040594
Received: 31 December 2020 / Revised: 29 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
(This article belongs to the Special Issue The Latest Clinical Advances in Thrombocytopenia)
Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatment including splenectomy or corticosteroids) are still observed when PTCP is not readily detected. The phenomenon is even more complex when occurring with different anticoagulants. In this review we present a case of multi-anticoagulant PTCP, where we studied different parameters including temperature, amikacin supplementation, measurement methods, and type of anticoagulant. Prevalence, clinical risk factors, pre-analytical and analytical factors, along with clinical implications, will be discussed. The detection of an anticoagulant-dependent PTCP does not necessarily imply the presence of specific disorders. Conversely, the incidence of PTCP seems higher in patients receiving low molecular weight heparin, during hospitalization, or in men aged 50 years or older. New analytical technologies, such as fluorescence or optical platelet counting, will be soon overturning traditional algorithms and represent valuable diagnostic aids. A practical laboratory approach, based on current knowledge of PTCP, is finally proposed for overcoming spuriously low platelet counts. View Full-Text
Keywords: pseudothrombocytopenia; platelets; hematimetry; fluorescence; amikacin; anticoagulants; COVID-19 pseudothrombocytopenia; platelets; hematimetry; fluorescence; amikacin; anticoagulants; COVID-19
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MDPI and ACS Style

Lardinois, B.; Favresse, J.; Chatelain, B.; Lippi, G.; Mullier, F. Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications. J. Clin. Med. 2021, 10, 594. https://doi.org/10.3390/jcm10040594

AMA Style

Lardinois B, Favresse J, Chatelain B, Lippi G, Mullier F. Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications. Journal of Clinical Medicine. 2021; 10(4):594. https://doi.org/10.3390/jcm10040594

Chicago/Turabian Style

Lardinois, Benjamin, Julien Favresse, Bernard Chatelain, Giuseppe Lippi, and François Mullier. 2021. "Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications" Journal of Clinical Medicine 10, no. 4: 594. https://doi.org/10.3390/jcm10040594

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