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Article

Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes

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Clinical Department of Paediatric Nephrology, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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2nd Clinical Department of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, M. Curie-Sklodowskiej Street 50-52, 50-369 Wroclaw, Poland
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Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego Street 2, 50-345 Wroclaw, Poland
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Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland
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Department of Dietetics, Wroclaw Medical University, Parkowa Street 34, 51-616 Wroclaw, Poland
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Department of Biochemistry and Immunochemistry, Division of Chemistry and Immunochemistry, Wroclaw Medical University, M. Sklodowskiej-Curie Street 48/50, 50-369 Wroclaw, Poland
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Statistical Analysis Centre, Wroclaw Medical University, K. Marcinkowski Street 2-6, 50-368 Wroclaw, Poland
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Clinical Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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Clinical Department of Internal Medicine, Hypertension and Clinical Oncology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
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Clinical Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland
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Clinical Department of Gynecology and Obstetrics, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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Clinical Department and Clinic of Cardiology, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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Department of Emergency Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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Clinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
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Centre for Heart Diseases, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Madhav C. Menon
J. Clin. Med. 2021, 10(23), 5522; https://doi.org/10.3390/jcm10235522 (registering DOI)
Received: 9 November 2021 / Revised: 22 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
(This article belongs to the Section Nephrology & Urology)
The disease caused by coronavirus SARS-CoV-2 (COVID-19) can affect almost all organs of the human body, including kidneys. We conducted a one-center study to comprehensively analyze the effects of kidney involvement on the course and outcomes in patients hospitalized with COVID-19, depending on the estimated glomerular filtration rate (eGFR) at admission. Out of the 1958 patients, 1342 (68.54%) had eGFR ≥ 60 mL/min/1.73 m2 (group A) and 616 (31.46%) had eGFR < 60 mL/min/1.73 m2 (group B). Group B was additionally divided into subgroups B1, B2, and B3 based on eGFR. We found that mortality rates during hospitalization, as well as after 90 and 180 days, were much higher in group B than group A. The highest mortality was observed in the B2 subgroup with eGFR of 15–29. The mortality of B patients was associated with comorbidities, respiratory dysfunction, immunological impairment, and more frequent development of AKI. AKI had a negative impact on patients’ survival, regardless of the initial renal function. At discharge, 7.4% of patients had serum creatinine levels 30% higher, or more, as compared to admission. The disease course and outcomes in COVID-19 patients are associated with baseline eGFR; however, AKI during hospitalization is a more significant predictor of poor prognosis regardless of the initial renal function. View Full-Text
Keywords: COVID-19; kidney dysfunction; acute kidney injury; hospitalization; mortality COVID-19; kidney dysfunction; acute kidney injury; hospitalization; mortality
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MDPI and ACS Style

Kilis-Pstrusinska, K.; Akutko, K.; Braksator, J.; Dancewicz, A.; Grosman-Dziewiszek, P.; Jamer, T.; Juszczyńska, K.; Konikowska, K.; Koruba, M.; Pupek, M.; Rusiecka, A.; Kujawa, K.; Adamik, B.; Doroszko, A.; Kaliszewski, K.; Matera-Witkiewicz, A.; Pomorski, M.; Protasiewicz, M.; Sokołowski, J.; Madziarska, K.; Jankowska, E.A. Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes. J. Clin. Med. 2021, 10, 5522. https://doi.org/10.3390/jcm10235522

AMA Style

Kilis-Pstrusinska K, Akutko K, Braksator J, Dancewicz A, Grosman-Dziewiszek P, Jamer T, Juszczyńska K, Konikowska K, Koruba M, Pupek M, Rusiecka A, Kujawa K, Adamik B, Doroszko A, Kaliszewski K, Matera-Witkiewicz A, Pomorski M, Protasiewicz M, Sokołowski J, Madziarska K, Jankowska EA. Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes. Journal of Clinical Medicine. 2021; 10(23):5522. https://doi.org/10.3390/jcm10235522

Chicago/Turabian Style

Kilis-Pstrusinska, Katarzyna, Katarzyna Akutko, Joanna Braksator, Anna Dancewicz, Patrycja Grosman-Dziewiszek, Tatiana Jamer, Katarzyna Juszczyńska, Klaudia Konikowska, Marta Koruba, Małgorzata Pupek, Agnieszka Rusiecka, Krzysztof Kujawa, Barbara Adamik, Adrian Doroszko, Krzysztof Kaliszewski, Agnieszka Matera-Witkiewicz, Michał Pomorski, Marcin Protasiewicz, Janusz Sokołowski, Katarzyna Madziarska, and Ewa A. Jankowska 2021. "Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes" Journal of Clinical Medicine 10, no. 23: 5522. https://doi.org/10.3390/jcm10235522

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