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Review

Ocular Involvement in Relapsing Polychondritis

1
Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan
2
Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School Hospital, Kochi University, Nankoku, Kochi 783-8505, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Andrzej Grzybowski
J. Clin. Med. 2021, 10(21), 4970; https://doi.org/10.3390/jcm10214970
Received: 28 September 2021 / Revised: 15 October 2021 / Accepted: 21 October 2021 / Published: 26 October 2021
(This article belongs to the Collection The Eye in Systemic Diseases)
Relapsing polychondritis (RPC) is a rare systemic immune-mediated disease characterized by recurrent inflammation of cartilaginous and proteoglycan-rich tissues throughout the body. Auricular, nasal, tracheal, and articular chondritis and arthritis are common systemic symptoms in patients with RPC. Ocular tissues are also targets of inflammation in RPC, and a variety of ocular symptoms are observed in approximately half of the patients with RPC. Scleritis/episcleritis, uveitis, and conjunctivitis are common symptoms associated with RPC. Less frequently, keratitis, retinopathy, optic neuropathy, muscle palsy, and orbital inflammation are also observed. Ocular inflammation could also be the first manifestation of RPC. Although RPC is a potentially fatal and sight-threatening disease, the rarity of the disease and its protean clinical presentation may lead to delayed diagnosis or misdiagnosis. Given the high prevalence of ocular involvement in RPC, to avoid misdiagnosis, physicians should be suspicious of RPC when they see patients with recurrent ocular inflammatory conditions and various systemic symptoms. In this article, we provide a comprehensive review of ocular manifestations associated with RPC. View Full-Text
Keywords: relapsing polychondritis; scleritis; uveitis; keratitis; conjunctivitis; retinopathy; optic neuropathy; ultrasonography; auricular chondritis relapsing polychondritis; scleritis; uveitis; keratitis; conjunctivitis; retinopathy; optic neuropathy; ultrasonography; auricular chondritis
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MDPI and ACS Style

Fukuda, K.; Mizobuchi, T.; Nakajima, I.; Kishimoto, T.; Miura, Y.; Taniguchi, Y. Ocular Involvement in Relapsing Polychondritis. J. Clin. Med. 2021, 10, 4970. https://doi.org/10.3390/jcm10214970

AMA Style

Fukuda K, Mizobuchi T, Nakajima I, Kishimoto T, Miura Y, Taniguchi Y. Ocular Involvement in Relapsing Polychondritis. Journal of Clinical Medicine. 2021; 10(21):4970. https://doi.org/10.3390/jcm10214970

Chicago/Turabian Style

Fukuda, Ken, Tomoka Mizobuchi, Isana Nakajima, Tatsuma Kishimoto, Yusaku Miura, and Yoshinori Taniguchi. 2021. "Ocular Involvement in Relapsing Polychondritis" Journal of Clinical Medicine 10, no. 21: 4970. https://doi.org/10.3390/jcm10214970

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