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Article

Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients

1
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
2
Clinical Trials Unit, University of Bern, 3012 Bern, Switzerland
3
Sitem Center for Translational Medicine and Biomedical Entrepreneurship, University of Bern, 3010 Bern, Switzerland
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Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
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Institute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland
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Department of Medicine, Neuchâtel Hospital Network, 2000 Neuchâtel, Switzerland
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Department of Internal Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
8
Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Department of Medicine, University of Toronto, Toronto, ON M5S, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Dragos Vinereanu
J. Clin. Med. 2021, 10(21), 4871; https://doi.org/10.3390/jcm10214871
Received: 23 September 2021 / Revised: 13 October 2021 / Accepted: 18 October 2021 / Published: 22 October 2021
(This article belongs to the Section Cardiology)
Background: The prevalence of atrial fibrillation (AF) is high in older patients. The present study aimed to estimate the age and sex specific prevalence of clinical and screen-detected atrial fibrillation (AF) in hospitalized patients. Methods: The STAR-FIB cohort study was a prospective cohort study recruiting participants from a large source population of hospitalized patients aged 65–84 years. The estimated size of the source population was 26,035 (95% CI 25,918–26,152), and 795 consenting patients without clinical AF were included in the cohort study after stratification by sex and age (49.2% females; mean age 74.7 years). Patients in the cohort study underwent three seven-day Holter ECGs in intervals of two months to screen for AF. Results: In the source population, the estimated prevalence of clinical AF was 22.2% (95% CI 18.4–26.1), 23.8% for males (95% CI 20.9–26.6) and 19.8% for females (95% CI 17.3–22.4; p for difference between sexes, 0.004). There was a linear trend for an increase in the prevalence of clinical AF with increasing age, overall and in both sexes. In the cohort study, AF was newly diagnosed in 38 patients, for an estimated prevalence of screen-detected AF of 4.9% overall (95% CI 3.3–6.6), 5.5% in males (95% CI 3.2–7.8) and 4.0% in females (95% CI 2.0–6.0; p for difference between sexes, 0.041). The estimated prevalence of screen-detected AF in the source population was 3.8% overall, 4.2% in males and 3.2% in females. Conclusion: In a large hospital-based patient population aged 65–84 years, the prevalence of clinical AF and of screen-detected AF was 22.2% and 3.8%, respectively, and significantly higher in males than females. View Full-Text
Keywords: atrial fibrillation; screening; paroxysmal; subclinical; silent; Holter ECG; prospective; cohort; hospitalized; age; sex atrial fibrillation; screening; paroxysmal; subclinical; silent; Holter ECG; prospective; cohort; hospitalized; age; sex
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    Doi: 10.4414/smw.2021.20421
MDPI and ACS Style

Roten, L.; Goulouti, E.; Lam, A.; Elchinova, E.; Nozica, N.; Spirito, A.; Wittmer, S.; Branca, M.; Servatius, H.; Noti, F.; Seiler, J.; Baldinger, S.H.; Haeberlin, A.; de Marchi, S.; Asatryan, B.; Rodondi, N.; Donzé, J.; Aujesky, D.; Tanner, H.; Reichlin, T.; Jüni, P. Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients. J. Clin. Med. 2021, 10, 4871. https://doi.org/10.3390/jcm10214871

AMA Style

Roten L, Goulouti E, Lam A, Elchinova E, Nozica N, Spirito A, Wittmer S, Branca M, Servatius H, Noti F, Seiler J, Baldinger SH, Haeberlin A, de Marchi S, Asatryan B, Rodondi N, Donzé J, Aujesky D, Tanner H, Reichlin T, Jüni P. Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients. Journal of Clinical Medicine. 2021; 10(21):4871. https://doi.org/10.3390/jcm10214871

Chicago/Turabian Style

Roten, Laurent, Eleni Goulouti, Anna Lam, Elena Elchinova, Nikolas Nozica, Alessandro Spirito, Severin Wittmer, Mattia Branca, Helge Servatius, Fabian Noti, Jens Seiler, Samuel H Baldinger, Andreas Haeberlin, Stefano de Marchi, Babken Asatryan, Nicolas Rodondi, Jacques Donzé, Drahomir Aujesky, Hildegard Tanner, Tobias Reichlin, and Peter Jüni. 2021. "Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients" Journal of Clinical Medicine 10, no. 21: 4871. https://doi.org/10.3390/jcm10214871

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