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Article

Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome

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Servicio de Cardiología, Hospital Universitario La Princesa, 28006 Madrid, Spain
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Servicio de Cardiología, Hospital Clínico Universitario de Santiago, CIBERCV, 15706 Santiago de Compostela, A Coruña, Spain
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Servicio de Cardiología, Hospital Álvaro Cunqueiro de Vigo, 36213 Vigo, Pontevedra, Spain
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Servicio de Cardiología, Hospital Universitario Vall d’Hebron, Universidad Autónoma de Barcelona, CIBERCV, 08035 Barcelona, Spain
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Servicio de Cardiología, Hospital Clínico Universitario de San Juan, 03550 Alicante, Spain
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Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV, Universidad Europea, Universidad Complutense, 28007 Madrid, Spain
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Servicio de Cardiología, Hospital Universitario de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, 43005 Tarragona, Spain
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Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, CIBERCV, 30120 Murcia, Spain
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Servicio de Cardiología, Hospital General Universitario de Alicante, 03010 Alicante, Spain
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Cardiology Department, Hospital General de Elche, 03203 Alicante, Spain
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Servicio de Cardiología, Hospital Universitario Ramón y Cajal de Madrid, CIBERCV, 28034 Madrid, Spain
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Servicio de Medicina Interna, Hospital Bellvitge, L’Hospitalet de Llobregat, 08097 Barcelona, Spain
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Servicio de Cardiología, Hospital Clínico Universitario de Valencia, INCLIVA, Universidad de Valencia, CIBERCV, 46014 Valencia, Spain
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Servicio de Cardiología, Hospital Bellvitge, L’Hospitalet de Llobregat, 08097 Barcelona, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Simone Biscaglia
J. Clin. Med. 2021, 10(19), 4403; https://doi.org/10.3390/jcm10194403
Received: 30 August 2021 / Revised: 15 September 2021 / Accepted: 21 September 2021 / Published: 26 September 2021
Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. View Full-Text
Keywords: elderly; non-ST-segment elevation acute coronary syndromes; women; diabetes mellitus elderly; non-ST-segment elevation acute coronary syndromes; women; diabetes mellitus
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MDPI and ACS Style

Díez-Villanueva, P.; García-Acuña, J.M.; Raposeiras-Roubin, S.; Barrabés, J.A.; Cordero, A.; Martínez-Sellés, M.; Bardají, A.; Marín, F.; Ruiz-Nodar, J.M.; Vicente-Ibarra, N.; Alonso Salinas, G.L.; Cid-Alvárez, B.; Abu Assi, E.; Formiga, F.; Núñez, J.; Núñez, E.; Ariza-Solé, A.; Sanchis, J. Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome. J. Clin. Med. 2021, 10, 4403. https://doi.org/10.3390/jcm10194403

AMA Style

Díez-Villanueva P, García-Acuña JM, Raposeiras-Roubin S, Barrabés JA, Cordero A, Martínez-Sellés M, Bardají A, Marín F, Ruiz-Nodar JM, Vicente-Ibarra N, Alonso Salinas GL, Cid-Alvárez B, Abu Assi E, Formiga F, Núñez J, Núñez E, Ariza-Solé A, Sanchis J. Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome. Journal of Clinical Medicine. 2021; 10(19):4403. https://doi.org/10.3390/jcm10194403

Chicago/Turabian Style

Díez-Villanueva, Pablo, Jose M. García-Acuña, Sergio Raposeiras-Roubin, Jose A. Barrabés, Alberto Cordero, Manuel Martínez-Sellés, Alfredo Bardají, Francisco Marín, Juan M. Ruiz-Nodar, Nuria Vicente-Ibarra, Gonzalo L. Alonso Salinas, Belén Cid-Alvárez, Emad Abu Assi, Frances Formiga, Julio Núñez, Eduardo Núñez, Albert Ariza-Solé, and Juan Sanchis. 2021. "Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome" Journal of Clinical Medicine 10, no. 19: 4403. https://doi.org/10.3390/jcm10194403

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