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Review

Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies

Experimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, ul. Jaracza 1, 00-378 Warsaw, Poland
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Academic Editors: Jerzy Samochowiec, Andreas Reif and Blazej Misiak
J. Clin. Med. 2021, 10(18), 4126; https://doi.org/10.3390/jcm10184126
Received: 6 June 2021 / Revised: 22 August 2021 / Accepted: 7 September 2021 / Published: 13 September 2021
(This article belongs to the Special Issue Hot Topics in Schizophrenia Research - Part I)
Cognitive biases are an important factor contributing to the development and symptom severity of psychosis. Despite the fact that various cognitive biases are contributing to psychosis, they are rarely investigated together. In the current systematic review, we aimed at investigating specific and shared functional neural correlates of two important cognitive biases: aberrant salience and source monitoring. We conducted a systematic search of fMRI studies of said cognitive biases. Eight studies on aberrant salience and eleven studies on source monitoring were included in the review. We critically discussed behavioural and neuroimaging findings concerning cognitive biases. Various brain regions are associated with aberrant salience and source monitoring in individuals with schizophrenia and the risk of psychosis. The ventral striatum and insula contribute to aberrant salience. The medial prefrontal cortex, superior and middle temporal gyrus contribute to source monitoring. The anterior cingulate cortex and hippocampus contribute to both cognitive biases, constituting a neural overlap. Our review indicates that aberrant salience and source monitoring may share neural mechanisms, suggesting their joint role in producing disrupted external attributions of perceptual and cognitive experiences, thus elucidating their role in positive symptoms of psychosis. Account bridging mechanisms of these two biases is discussed. Further studies are warranted. View Full-Text
Keywords: aberrant salience; source monitoring; psychosis; cognitive biases; self-disturbance; neural; fMRI aberrant salience; source monitoring; psychosis; cognitive biases; self-disturbance; neural; fMRI
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MDPI and ACS Style

Kowalski, J.; Aleksandrowicz, A.; Dąbkowska, M.; Gawęda, Ł. Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies. J. Clin. Med. 2021, 10, 4126. https://doi.org/10.3390/jcm10184126

AMA Style

Kowalski J, Aleksandrowicz A, Dąbkowska M, Gawęda Ł. Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies. Journal of Clinical Medicine. 2021; 10(18):4126. https://doi.org/10.3390/jcm10184126

Chicago/Turabian Style

Kowalski, Joachim, Adrianna Aleksandrowicz, Małgorzata Dąbkowska, and Łukasz Gawęda. 2021. "Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies" Journal of Clinical Medicine 10, no. 18: 4126. https://doi.org/10.3390/jcm10184126

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