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Article

Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process

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Department of Gynecology-Obstetric and Reproductive Medicine, AP-HM, Hôpital La Conception, 13005 Marseille, France
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Aix-Marseille Université, IMBE, CNRS, IRD, Avignon Université, 13005 Marseille, France
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Unité d’Epidémiologie Clinique, Hôpital Universitaire Robert Debré, AP-HP Nord-Université de Paris, Inserm, CIC 1426, 75019 Paris, France
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ECEVE UMR 1123, Université de Paris, Inserm, 75019 Paris, France
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Department of Gynecology-Obstetric and Reproductive Medicine, GRC6-UPMC, Centre Expert en Endométriose (C3E), Université Pierre-et-Marie-Curie Paris 6, Hôpital Tenon, CHU de Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France
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Department of Gynecology-Obstetric and Reproductive Medicine, CHU Rouen, 37 bd Gambetta, 76000 Rouen, France
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Service de Biologie de la Reproduction—CECOS, APHP Centre—Université de Paris, Site Cochin, Inserm U1016, 75014 Paris, France
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Department of Gynecology-Obstetric, UFR SMBH Leonard de Vinci, CH René Dubos, 95000 Cergy-Pontoise, France
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Université Sorbonne Paris Nord—Paris 13, 93200 Saint-Denis, France
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Institut Francophone de Recherche et d’Etudes Appliquées à la Reproduction, Ifreares Toulouse, 31000 Toulouse, France
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Department of Gynecologic Surgery and IVF, Clermont-Ferrand, University Hospital Clermont-Ferrand, 63000 Clermont-Ferrand, France
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Clinique Saint Roch, Department of Gynecology-Obstetric and Reproductive Medicine, 34000 Montpellier, France
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Department of Reproductive Medicine and Fertility Preservation, AP-HP Hôpital Jean Verdier, 93143 Bondy, France
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Centre d’Endométriose, Clinique Tivoli Ducos, 33000 Bordeaux, France
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EndoFrance, Association Française de lutte contre l’Endométriose, 70190 Tresilley, France
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Department of Gynecology-Obstetric and Reproductive Medicine, CHU Poitiers, 86000 Poitiers, France
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Inserm CIC-P 1402, 86021 Poitiers, France
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Department of Gynecology-Obstetric, CH Moulins Yzeure, 03000 Moulins, France
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Department of Gynecology and Obstetrics, CHI Poissy-Saint-Germain-en Laye, 78300 Poissy, France
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Research Unit 7285 Risk and Safety in Clinical Medicine for Women and Perinatal Health, Paris-Saclay University, 78300 Poissy, France
*
Author to whom correspondence should be addressed.
Members of the PreFerBE expert panel are listed in the Acknowledgments.
Academic Editor: Kenny Rodriguez-Wallberg
J. Clin. Med. 2021, 10(17), 3810; https://doi.org/10.3390/jcm10173810
Received: 4 July 2021 / Revised: 4 August 2021 / Accepted: 18 August 2021 / Published: 25 August 2021
International guidelines are published to provide standardized information and fertility preservation (FP) care for adults and children. The purpose of the study was to conduct a modified Delphi process for generating FP guidelines for BGD. A steering committee identified 42 potential FP practices for BGD. Then 114 key stakeholders were asked to participate in a modified Delphi process via two online survey rounds and a final meeting. Consensus was reached for 28 items. Among them, stakeholders rated age-specific information concerning the risk of diminished ovarian reserve after surgery as important but rejected proposals setting various upper and lower age limits for FP. All women should be informed about the benefit/risk balance of oocyte vitrification—in particular about the likelihood of live birth according to age. FP should not be offered in rASRM stages I and II endometriosis without endometriomas. These guidelines could be useful for gynecologists to identify situations at risk of infertility and to better inform women with BGDs who might need personalized counseling for FP. View Full-Text
Keywords: fertility preservation; oocyte vitrification; benign gynecologic disease; modified Delphi method; consensus study fertility preservation; oocyte vitrification; benign gynecologic disease; modified Delphi method; consensus study
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MDPI and ACS Style

Courbiere, B.; Le Roux, E.; Mathieu d’Argent, E.; Torre, A.; Patrat, C.; Poncelet, C.; Montagut, J.; Gremeau, A.-S.; Creux, H.; Peigné, M.; Chanavaz-Lacheray, I.; Dirian, L.; Fritel, X.; Pouly, J.-L.; Fauconnier, A.; on behalf of the PreFerBe Expert Panel. Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process. J. Clin. Med. 2021, 10, 3810. https://doi.org/10.3390/jcm10173810

AMA Style

Courbiere B, Le Roux E, Mathieu d’Argent E, Torre A, Patrat C, Poncelet C, Montagut J, Gremeau A-S, Creux H, Peigné M, Chanavaz-Lacheray I, Dirian L, Fritel X, Pouly J-L, Fauconnier A, on behalf of the PreFerBe Expert Panel. Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process. Journal of Clinical Medicine. 2021; 10(17):3810. https://doi.org/10.3390/jcm10173810

Chicago/Turabian Style

Courbiere, Blandine, Enora Le Roux, Emmanuelle Mathieu d’Argent, Antoine Torre, Catherine Patrat, Christophe Poncelet, Jacques Montagut, Anne-Sophie Gremeau, Hélène Creux, Maëliss Peigné, Isabella Chanavaz-Lacheray, Lara Dirian, Xavier Fritel, Jean-Luc Pouly, Arnaud Fauconnier, and on behalf of the PreFerBe Expert Panel. 2021. "Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process" Journal of Clinical Medicine 10, no. 17: 3810. https://doi.org/10.3390/jcm10173810

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