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Article

Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder

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Addiction Unit, Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain
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Department of Medicine, Universitat Autònoma de Barcelona, 08916 Badalona, Barcelona, Spain
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Department of Internal Medicine, Hospital Universitari de Bellvitge, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L’Hospitalet de Llobregat, Barcelona, Spain
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Department of Biochemistry, Hospital Universitari Germans Trias i Pujol de Badalona, 08916 Badalona, Barcelona, Spain
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Mental Health and Addiction Service, Badalona Serveis Assistencials-BSA, 08911 Badalona, Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Ana Adan
J. Clin. Med. 2021, 10(16), 3496; https://doi.org/10.3390/jcm10163496
Received: 19 June 2021 / Revised: 2 August 2021 / Accepted: 5 August 2021 / Published: 8 August 2021
(This article belongs to the Section Clinical Psychology)
Background: The association between markers of inflammation (interleukin (IL)-6 and IL-10), monocyte activation (sCD163 and sCD14), and microbial translocation (lipopolysaccharide (LPS) and LPS binding protein) and liver fibrosis in patients with alcohol use disorder (AUD) and no overt liver disease is not well established. Methods: We studied patients admitted for treatment of AUD at two hospitals in Barcelona. Advanced liver fibrosis (ALF) was defined as FIB-4 > 3.25. Results: A total of 353 participants (76.3% male) were included and 94 (26.5%) had ALF. In adjusted correlation analyses, sCD163, sCD14, IL-6, IL-10, and LPS binding protein levels directly correlated with FIB-4 values (adjusted correlation coefficients 0.214, 0.452, 0.317, 0.204, and 0.171, respectively). However, LPS levels were inversely associated with FIB-4 (−0.283). All plasma marker levels in the highest quartile, except LPS, were associated with ALF (sCD163, sCD14, IL-6, IL-10, and LPS binding protein: adjusted odds ratio (aOR) 11.49 (95% confidence interval 6.42–20.56), 1.87 (1.11–3.16), 2.99 (1.79–5.01), 1.84 (1.11–3.16), and 2.13 (1.30–3.50), respectively). Conversely, LPS levels in the lowest quartile were associated with ALF (aOR 2.58 (1.48–4.58), p < 0.01). Conclusion: In AUD patients, plasma levels of the markers of inflammation, monocyte activation, and microbial translocation are associated with ALF. View Full-Text
Keywords: alcohol use disorder; monocyte activation; inflammation; microbial translocation; liver fibrosis alcohol use disorder; monocyte activation; inflammation; microbial translocation; liver fibrosis
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MDPI and ACS Style

Fuster, D.; Garcia-Calvo, X.; Farré, O.; Zuluaga, P.; Bolao, F.; Leis, A.; Hernández-Rubio, A.; Rivas, I.; Muga, R. Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder. J. Clin. Med. 2021, 10, 3496. https://doi.org/10.3390/jcm10163496

AMA Style

Fuster D, Garcia-Calvo X, Farré O, Zuluaga P, Bolao F, Leis A, Hernández-Rubio A, Rivas I, Muga R. Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder. Journal of Clinical Medicine. 2021; 10(16):3496. https://doi.org/10.3390/jcm10163496

Chicago/Turabian Style

Fuster, Daniel, Xavier Garcia-Calvo, Oriol Farré, Paola Zuluaga, Ferran Bolao, Alba Leis, Anna Hernández-Rubio, Inmaculada Rivas, and Robert Muga. 2021. "Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder" Journal of Clinical Medicine 10, no. 16: 3496. https://doi.org/10.3390/jcm10163496

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