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Article

Preliminary Results of Robotic Lobectomy in Stage IIIA-N2 NSCLC after Induction Treatment: A Case Control Study

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Division of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy
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Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy
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Division of Epidemiology and Biostatistics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy
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Division of Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Sukhwinder Singh Sohal
J. Clin. Med. 2021, 10(16), 3465; https://doi.org/10.3390/jcm10163465
Received: 4 June 2021 / Revised: 26 July 2021 / Accepted: 1 August 2021 / Published: 5 August 2021
(This article belongs to the Special Issue Applications of Robotic Surgery in Thoracic Diseases)
Despite there already being many studies on robotic surgery as a minimally invasive approach for non-small-cell lung cancer (NSCLC) patients, the use of this technique for stage III disease is still poorly described. These are the preliminary results of our prospective study on the safety and effectiveness of robotic approaches in patients with locally advanced NSCLC in terms of postoperative complications and oncological outcomes. Since 2016, we prospectively investigated 19 consecutive patients with NSCLC stage IIIA-pN2 (diagnosed by EBUS-TBNA) who underwent lobectomy and radical lymph node dissection with robotic approaches after induction treatment. Furthermore, we matched a case-control study with 46 patients treated with open surgery during the same period of time, with similar age, comorbidities, clinical stage and tumor size. The individual matched population was composed of 16 robot-assisted thoracic surgeries and 16 patients who underwent open surgery. The median time range of resection was inferior in the open group compared to robotic lobectomy (243 vs. 161 min; p < 0.001). Lymph node resection and positivity were not significantly different (p = 0.96 and p = 0.57, respectively). Moreover, no difference was observed for PFS (p = 0.16) or OS (p = 0.41). In conclusion, we demonstrated that the early outcomes and oncological results of N2-patients after robotic lobectomy were similar to those who had open surgery. Considering the advantages of minimally invasive surgery, robot-assisted lobectomy appears to be a safe approach to patients with locally advanced diseases. View Full-Text
Keywords: lung cancer; induction therapy; robotic surgery lung cancer; induction therapy; robotic surgery
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MDPI and ACS Style

Casiraghi, M.; Petrella, F.; Sedda, G.; Mazzella, A.; Guarize, J.; Maisonneuve, P.; De Marinis, F.; Spaggiari, L. Preliminary Results of Robotic Lobectomy in Stage IIIA-N2 NSCLC after Induction Treatment: A Case Control Study. J. Clin. Med. 2021, 10, 3465. https://doi.org/10.3390/jcm10163465

AMA Style

Casiraghi M, Petrella F, Sedda G, Mazzella A, Guarize J, Maisonneuve P, De Marinis F, Spaggiari L. Preliminary Results of Robotic Lobectomy in Stage IIIA-N2 NSCLC after Induction Treatment: A Case Control Study. Journal of Clinical Medicine. 2021; 10(16):3465. https://doi.org/10.3390/jcm10163465

Chicago/Turabian Style

Casiraghi, Monica, Francesco Petrella, Giulia Sedda, Antonio Mazzella, Juliana Guarize, Patrick Maisonneuve, Filippo De Marinis, and Lorenzo Spaggiari. 2021. "Preliminary Results of Robotic Lobectomy in Stage IIIA-N2 NSCLC after Induction Treatment: A Case Control Study" Journal of Clinical Medicine 10, no. 16: 3465. https://doi.org/10.3390/jcm10163465

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