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Article

Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography

1
Department of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
2
Department of Radiology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-8555, Japan
3
Department of Surgery, Breast Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
4
Department of Comprehensive Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Hans-Jonas Meyer
J. Clin. Med. 2021, 10(14), 3173; https://doi.org/10.3390/jcm10143173
Received: 14 June 2021 / Revised: 16 July 2021 / Accepted: 16 July 2021 / Published: 19 July 2021
This retrospective study examined the relationship between the standardized uptake value max (SUVmax) of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and the prognostic stage of breast cancer. We examined 358 breast cancers in 334 patients who underwent 18F-FDG PET/CT for initial staging between January 2016 and December 2019. We extracted data including SUVmax of 18F-FDG PET and pathological biomarkers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and nuclear grade. Anatomical and prognostic stages were determined per the American Joint Committee on Cancer (eighth edition). We examined whether there were statistical differences in SUVmax between each prognostic stage. The mean SUVmax values for clinical prognostic stages were as follow: stage 0, 2.2 ± 1.4; stage IA, 2.6 ± 2.1; stage IB, 4.2 ± 3.5; stage IIA, 5.2 ± 2.8; stage IIB, 7.7 ± 6.7; and stage III + IV, 7.0 ± 4.5. The SUVmax values for pathological prognostic stages were as follows: stage 0, 2.2 ± 1.4; stage IA, 2.8 ± 2.2; stage IB, 5.4 ± 3.6; stage IIA, 6.3 ± 3.1; stage IIB, 9.2 ± 7.5, and stage III + IV, 6.2 ± 5.2. There were significant differences in mean SUVmax between clinical prognostic stage 0 and ≥II (p < 0.001) and I and ≥II (p < 0.001). There were also significant differences in mean SUVmax between pathological prognostic stage 0 and ≥II (p < 0.001) and I and ≥II (p < 0.001). In conclusion, mean SUVmax increased with all stages up to prognostic stage IIB, and there were significant differences between several stages. The SUVmax of 18F-FDG PET/CT may contribute to prognostic stage stratification, particularly in early cases of breast cancers. View Full-Text
Keywords: breast cancer; positron emission tomography; standard uptake value; prognostic stage; American Joint Committee on Cancer breast cancer; positron emission tomography; standard uptake value; prognostic stage; American Joint Committee on Cancer
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MDPI and ACS Style

Mori, M.; Fujioka, T.; Kubota, K.; Katsuta, L.; Yashima, Y.; Nomura, K.; Yamaga, E.; Tsuchiya, J.; Hosoya, T.; Oda, G.; Nakagawa, T.; Onishi, I.; Tateishi, U. Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. J. Clin. Med. 2021, 10, 3173. https://doi.org/10.3390/jcm10143173

AMA Style

Mori M, Fujioka T, Kubota K, Katsuta L, Yashima Y, Nomura K, Yamaga E, Tsuchiya J, Hosoya T, Oda G, Nakagawa T, Onishi I, Tateishi U. Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. Journal of Clinical Medicine. 2021; 10(14):3173. https://doi.org/10.3390/jcm10143173

Chicago/Turabian Style

Mori, Mio, Tomoyuki Fujioka, Kazunori Kubota, Leona Katsuta, Yuka Yashima, Kyoko Nomura, Emi Yamaga, Junichi Tsuchiya, Tokuko Hosoya, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, and Ukihide Tateishi. 2021. "Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography" Journal of Clinical Medicine 10, no. 14: 3173. https://doi.org/10.3390/jcm10143173

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