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Article

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

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Czech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC, JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
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Department of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
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Department of Prosthetic Dentistry, Faculty of Dentistry, Yeditepe University, Bagdat Caddesi No. 238, Goztepe, Kadikoy, Istanbul 34728, Turkey
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Department of Gynaecology and Obstetrics, Faculty of Medicine, Namık Kemal University, Namık Kemal Kampüs Caddesi No. 1, Merkez, Tekirdağ 59030, Turkey
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Department of Nursing and Midwifery, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
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Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
These authors have contributed equally.
Academic Editors: Giuseppe La Torre and Emmanuel Andres
J. Clin. Med. 2021, 10(12), 2629; https://doi.org/10.3390/jcm10122629
Received: 20 April 2021 / Revised: 4 June 2021 / Accepted: 11 June 2021 / Published: 15 June 2021
(This article belongs to the Section Infectious Diseases)
Background: COVID-19 vaccine hesitancy is a serious threat to mass vaccination strategies that need to be accelerated currently in order to achieve a substantial level of community immunity. Independent (non-sponsored) studies have a great potential to enhance public confidence in vaccines and accelerate their uptake process. Methods: A nationwide cross-sectional study for the side effects (SE) of CoronaVac was carried out in February 2021 among Turkish healthcare workers who were recently vaccinated. The questionnaire inquired about local and systemic SEs that occurred in the short-term, within four weeks, following vaccination. Results: A total of 780 healthcare workers were included in this study; 62.5% of them experienced at least one SE. Injection site pain (41.5%) was the most common local SE, while fatigue (23.6%), headache (18.7%), muscle pain (11.2%) and joint pain (5.9%) were the common systemic SEs. Female healthcare workers (67.9%) were significantly more affected by local and systemic SEs than male colleagues (51.4%). Younger age, previous infection, and compromised health status (chronic illnesses and regular medicines uptake) can be associated with an increased risk of CoronaVac SEs; Conclusions: The independent research shows a higher prevalence of CoronaVac SEs than what is reported by phase I–III clinical trials. In general, the results of this study confirm the overall safety of CoronaVac and suggest potential risk factors for its SEs. Gender-based differences and SEs distribution among age groups are worth further investigation. View Full-Text
Keywords: CoronaVac; COVID-19; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence; Turkey CoronaVac; COVID-19; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence; Turkey
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MDPI and ACS Style

Riad, A.; Sağıroğlu, D.; Üstün, B.; Pokorná, A.; Klugarová, J.; Attia, S.; Klugar, M. Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey. J. Clin. Med. 2021, 10, 2629. https://doi.org/10.3390/jcm10122629

AMA Style

Riad A, Sağıroğlu D, Üstün B, Pokorná A, Klugarová J, Attia S, Klugar M. Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey. Journal of Clinical Medicine. 2021; 10(12):2629. https://doi.org/10.3390/jcm10122629

Chicago/Turabian Style

Riad, Abanoub, Derya Sağıroğlu, Batuhan Üstün, Andrea Pokorná, Jitka Klugarová, Sameh Attia, and Miloslav Klugar. 2021. "Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey" Journal of Clinical Medicine 10, no. 12: 2629. https://doi.org/10.3390/jcm10122629

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