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Article

Are Tubular Injury Markers NGAL and KIM-1 Useful in Pediatric Neurogenic Bladder?

Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngtona Str, 15-274 Białystok, Poland
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Academic Editors: Kinga Musiał, Katarzyna Taranta-Janusz and Emmanuel Andrès
J. Clin. Med. 2021, 10(11), 2353; https://doi.org/10.3390/jcm10112353
Received: 9 May 2021 / Revised: 22 May 2021 / Accepted: 25 May 2021 / Published: 27 May 2021
The lack of early biomarkers of renal damage in children with neurogenic bladder (NB) prompts us to investigate the role of promising proteins: neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). This prospective analysis was conducted on 58 children with NB and 25 healthy children. We assessed urinary levels of NGAL and KIM-1 in both groups. Age, sex, anthropometric measurements, activity assessment, renal function, and urodynamics parameters were analyzed. The differences between the median uNGAL and uKIM-1 in the NB group compared to control were recorded. However, only uNGAL levels were statistically significantly higher. Statistically significant correlation was found between gender, recurrent urinary tract infections, bladder trabeculation, its compliance, activity assessment, and uNGAL. To conclude, elevated levels of uNGAL may be considered a biomarker of tubular injury in children with NB due to MMC in contrast to uKIM-1. View Full-Text
Keywords: neurogenic bladder; myelomeningocele; markers neurogenic bladder; myelomeningocele; markers
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MDPI and ACS Style

Bagińska, J.; Korzeniecka-Kozerska, A. Are Tubular Injury Markers NGAL and KIM-1 Useful in Pediatric Neurogenic Bladder? J. Clin. Med. 2021, 10, 2353. https://doi.org/10.3390/jcm10112353

AMA Style

Bagińska J, Korzeniecka-Kozerska A. Are Tubular Injury Markers NGAL and KIM-1 Useful in Pediatric Neurogenic Bladder? Journal of Clinical Medicine. 2021; 10(11):2353. https://doi.org/10.3390/jcm10112353

Chicago/Turabian Style

Bagińska, Joanna, and Agata Korzeniecka-Kozerska. 2021. "Are Tubular Injury Markers NGAL and KIM-1 Useful in Pediatric Neurogenic Bladder?" Journal of Clinical Medicine 10, no. 11: 2353. https://doi.org/10.3390/jcm10112353

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