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Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
Review

Surgical Management and Reconstruction of Diaphragm, Pericardium and Chest Wall in Mesothelioma Surgery: A Review

Division of Thoracic Surgery, IRCCS Azienda Ospedaliera Universitaria di Bologna, 40138 Bologna, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
J. Clin. Med. 2021, 10(11), 2330; https://doi.org/10.3390/jcm10112330
Received: 13 April 2021 / Revised: 20 May 2021 / Accepted: 25 May 2021 / Published: 26 May 2021
Mesothelioma is an aggressive disease arising from parietal pleura. Surgery is a valuable option in the frame of a multimodality treatment. Several surgical approaches have been standardized with the aim of a macroscopic complete resection; these often require homolateral diaphragm and pericardial resection and reconstruction. Extrapleural pneumonectomy (EPP) and extended pleurectomy decortication (EPD) have been recognized as radical surgical procedures. Nevertheless, both operations are technically challenging and associated with a significant rate of peri-operative morbidity and non-negligible mortality. The diaphragmatic and pericardial reconstruction technique is mandatory to avoid respiratory impairment and to reduce post-operative complications like gastric and cardiac herniation. Moreover, in the case of localized chest wall recurrence, surgery might be considered a valuable therapeutical option for highly selected and fit patients. All the technical aspects of the resection and reconstruction of the diaphragm, pericardium, and chest wall are described as well as the possible use of new minimally invasive techniques. In addition, the choice of different prosthetic materials, considering the most recent innovations in the field, are discussed. View Full-Text
Keywords: malignant pleural mesothelioma; surgery; diaphragm; pericardium; chest wall malignant pleural mesothelioma; surgery; diaphragm; pericardium; chest wall
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MDPI and ACS Style

Bertoglio, P.; Garelli, E.; Brandolini, J.; Kawamukai, K.; Antonacci, F.; Ricciardi, S.; Cipolli, A.; Bonfanti, B.; Forti Parri, S.N.; Daddi, N.; Dolci, G.; Solli, P. Surgical Management and Reconstruction of Diaphragm, Pericardium and Chest Wall in Mesothelioma Surgery: A Review. J. Clin. Med. 2021, 10, 2330. https://doi.org/10.3390/jcm10112330

AMA Style

Bertoglio P, Garelli E, Brandolini J, Kawamukai K, Antonacci F, Ricciardi S, Cipolli A, Bonfanti B, Forti Parri SN, Daddi N, Dolci G, Solli P. Surgical Management and Reconstruction of Diaphragm, Pericardium and Chest Wall in Mesothelioma Surgery: A Review. Journal of Clinical Medicine. 2021; 10(11):2330. https://doi.org/10.3390/jcm10112330

Chicago/Turabian Style

Bertoglio, Pietro, Elena Garelli, Jury Brandolini, Kenji Kawamukai, Filippo Antonacci, Sara Ricciardi, Alessandro Cipolli, Barbara Bonfanti, Sergio N. Forti Parri, Niccolò Daddi, Giampiero Dolci, and Piergiorgio Solli. 2021. "Surgical Management and Reconstruction of Diaphragm, Pericardium and Chest Wall in Mesothelioma Surgery: A Review" Journal of Clinical Medicine 10, no. 11: 2330. https://doi.org/10.3390/jcm10112330

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