Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets
Department of Physics and Astronomy, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4M1, Canada
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Received: 12 June 2017 / Revised: 26 July 2017 / Accepted: 23 August 2017 / Published: 31 August 2017
aggregates play a causative role in Alzheimer’s disease. These aggregates are a product of the physical environment provided by the basic neuronal membrane, composed of a lipid bilayer. The intrinsic properties of the lipid bilayer allow amyloid-
peptides to nucleate and form well-ordered cross-
sheets within the membrane. Here, we correlate the aggregation of the hydrophobic fragment of the amyloid-
, with the hydrophobicity, fluidity, and charge density of a lipid bilayer. We summarize recent biophysical studies of model membranes and relate these to the process of aggregation in physiological systems.
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MDPI and ACS Style
Khondker, A.; Alsop, R.J.; Rheinstädter, M.C. Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets. Membranes 2017, 7, 49.
Khondker A, Alsop RJ, Rheinstädter MC. Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets. Membranes. 2017; 7(3):49.
Khondker, Adree; Alsop, Richard J.; Rheinstädter, Maikel C. 2017. "Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets." Membranes 7, no. 3: 49.
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