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The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People

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Faculty of Chemistry, University in Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland
2
Department of Analytical Chemistry, Medical University of Białystok, Mickiewicza 2d, 15-222 Białystok, Poland
3
Dermatological Specialized Center ”DERMAL” NZOZ in Białystok, Nowy Swiat 17/5, 15-453 Białystok, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Mingxu You
Membranes 2021, 11(2), 111; https://doi.org/10.3390/membranes11020111
Received: 10 January 2021 / Revised: 29 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
(This article belongs to the Section Biological Membrane Composition and Structures)
The development of psoriasis is accompanied by oxidative stress, which can modify the components of skin cells. Therefore, the aim of this study was to evaluate the effect of cannabidiol (CBD), an antioxidant and anti-inflammatory phytocannabinoid, on the composition and physicochemical properties of the membranes of healthy and psoriatic keratinocytes and fibroblasts exposed to ultraviolet A (UVA) and ultraviolet B (UVB) radiation. In psoriasis-altered cells, decreased levels of the main groups of phospholipids and increased levels of sialic acid and malondialdehyde (MDA), a lipid peroxidation product, as well as negative charge of cell membranes compared to non-diseased cells, were found. On the other hand, UVA/B radiation increased the levels of phospholipids and MDA in both groups of cells. Moreover, psoriatic cells were characterized by lower levels of sialic acid and negative charge of cell membranes, while non-diseased cells showed the opposite response. The CBD treatment intensified some of the changes (phospholipid content and membrane charge) caused by the radiation of psoriatic cells, while it prevented these changes in the cells of healthy people. The results of this study indicate that CBD can prevent structural and functional changes to the membranes of healthy skin cells during phototherapy for psoriasis. View Full-Text
Keywords: psoriasis; cannabidiol; UV radiation; fibroblasts; keratinocytes; electrical properties; phospholipids; sialic acid; malondialdehyde psoriasis; cannabidiol; UV radiation; fibroblasts; keratinocytes; electrical properties; phospholipids; sialic acid; malondialdehyde
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MDPI and ACS Style

Szachowicz-Petelska, B.; Łuczaj, W.; Wroński, A.; Jastrząb, A.; Dobrzyńska, I. The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People. Membranes 2021, 11, 111. https://doi.org/10.3390/membranes11020111

AMA Style

Szachowicz-Petelska B, Łuczaj W, Wroński A, Jastrząb A, Dobrzyńska I. The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People. Membranes. 2021; 11(2):111. https://doi.org/10.3390/membranes11020111

Chicago/Turabian Style

Szachowicz-Petelska, Barbara, Wojciech Łuczaj, Adam Wroński, Anna Jastrząb, and Izabela Dobrzyńska. 2021. "The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People" Membranes 11, no. 2: 111. https://doi.org/10.3390/membranes11020111

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