Next Article in Journal
Resistance to Ticks and the Path to Anti-Tick and Transmission Blocking Vaccines
Next Article in Special Issue
Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity
Previous Article in Journal
In Vivo Production of HN Protein Increases the Protection Rates of a Minicircle DNA Vaccine against Genotype VII Newcastle Disease Virus
Previous Article in Special Issue
Immunotherapy and Vaccination in Surgically Resectable Non-Small Cell Lung Cancer (NSCLC)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Vaccines
Volume 9
Issue 7
10.3390/vaccines9070724
vaccines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies

by
Gihoon You
1,
Jonghwa Won
2,
Yangsoon Lee
2,
Dain Moon
1,
Yunji Park
3,
Sang Hoon Lee
2 and
Seung-Woo Lee
1,*
1
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
2
ABL Bio Inc., Seongnam 13488, Korea
3
Biotechcenter, POSTECH, Pohang 37673, Korea
*
Author to whom correspondence should be addressed.
Vaccines 2021, 9(7), 724; https://doi.org/10.3390/vaccines9070724
Submission received: 30 April 2021 / Revised: 5 June 2021 / Accepted: 28 June 2021 / Published: 2 July 2021
(This article belongs to the Special Issue Cancer Vaccines and Immunotherapy for Tumor Prevention and Treatment)
Browse Figures
Review Reports Versions Notes

Abstract

Following the clinical success of cancer immunotherapies such as immune checkpoint inhibitors blocking B7/CTLA-4 or PD-1/PD-L1 signaling and ongoing numerous combination therapies in the clinic,3 bispecific antibodies (BsAbs) are now emerging as a growing class of immunotherapies with the potential to improve clinical efficacy and safety further. Here, we describe four classes of BsAbs: (a) immune effector cell redirectors; (b) tumor-targeted immunomodulators; (c) dual immunomodulators; and (d) dual tumor-targeting BsAbs. This review describes each of these classes of BsAbs and presents examples of BsAbs in development. We reviewed the biological rationales and characteristics of BsAbs and summarized the current status and limitations of clinical development of BsAbs and strategies to overcome limitations. The field of BsAb-based cancer immunotherapy is growing, and more data from clinical trials are accumulating. Thus, BsAbs could be the next generation of new treatment options for cancer patients.
Keywords: bispecific antibody; cancer immunotherapy bispecific antibody; cancer immunotherapy

Share and Cite

MDPI and ACS Style

You, G.; Won, J.; Lee, Y.; Moon, D.; Park, Y.; Lee, S.H.; Lee, S.-W. Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies. Vaccines 2021, 9, 724. https://doi.org/10.3390/vaccines9070724

AMA Style

You G, Won J, Lee Y, Moon D, Park Y, Lee SH, Lee S-W. Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies. Vaccines. 2021; 9(7):724. https://doi.org/10.3390/vaccines9070724

Chicago/Turabian Style

You, Gihoon, Jonghwa Won, Yangsoon Lee, Dain Moon, Yunji Park, Sang Hoon Lee, and Seung-Woo Lee. 2021. "Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies" Vaccines 9, no. 7: 724. https://doi.org/10.3390/vaccines9070724

APA Style

You, G., Won, J., Lee, Y., Moon, D., Park, Y., Lee, S. H., & Lee, S.-W. (2021). Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies. Vaccines, 9(7), 724. https://doi.org/10.3390/vaccines9070724

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop