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Communication

Antibody Response to a Live-Modified Virus Vaccine against Bovine Viral Diarrhoea in Dairy Cattle in a Field Trial

1
Division of Infectious Diseases of Animals and Veterinary Administration, Department of Epizootiology and Clinic of Birds and Exotic Animals, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 45, 50-366 Wroclaw, Poland
2
Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences–SGGW, ul. Nowoursynowska 159c, 02-776 Warsaw, Poland
3
Department of Virology, National Veterinary Research Institute, al. Partyzantów 57, 24-100 Puławy, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Kerstin Wernike
Vaccines 2021, 9(3), 259; https://doi.org/10.3390/vaccines9030259
Received: 24 February 2021 / Revised: 11 March 2021 / Accepted: 11 March 2021 / Published: 15 March 2021
(This article belongs to the Special Issue Bovine Viral Diarrhea/Mucosal Disease)
(1) Background: The objective of the study was to evaluate the long-term antibody response of dairy cows to a single dose of a commercial modified-live virus (MLV) vaccine against bovine viral diarrhea (Mucosiffa® CEVA Sante Animale, Liburne, France). (2) Methods: The study was carried out in a dairy cattle herd counting 290 animals negative for bovine viral diarrhoea virus (BVDV). The vaccination was implemented following the manufacturer’s instructions. Twelve dairy cows were randomly selected before the study, and blood samples were collected right before the vaccination and then 12 times at 1-month intervals. The serum samples were screened using a virus neutralization test (VNT) and ELISA. (3) Results: Both tests showed that antibody titers increased significantly in all animals within the first month post-vaccination, and continued to increase significantly until the second (VNT) and third (ELISA) month post-vaccination. Antibody titers remained high and stable until the end of the study. Moreover, cows did not show any adverse reactions or clinical symptoms of the disease. (4) Conclusion: The results of this study indicated that the administration of one dose MLV vaccine was able to stimulate long-lasting (12-months) and strong antibody response in all vaccinated cows. View Full-Text
Keywords: BVDV; dairy cattle; life-modified virus vaccine; vaccination BVDV; dairy cattle; life-modified virus vaccine; vaccination
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MDPI and ACS Style

Klimowicz-Bodys, M.D.; Płoneczka-Janeczko, K.; Czopowicz, M.; Polak, M.P.; Lachowicz-Wolak, A.; Rypuła, K. Antibody Response to a Live-Modified Virus Vaccine against Bovine Viral Diarrhoea in Dairy Cattle in a Field Trial. Vaccines 2021, 9, 259. https://doi.org/10.3390/vaccines9030259

AMA Style

Klimowicz-Bodys MD, Płoneczka-Janeczko K, Czopowicz M, Polak MP, Lachowicz-Wolak A, Rypuła K. Antibody Response to a Live-Modified Virus Vaccine against Bovine Viral Diarrhoea in Dairy Cattle in a Field Trial. Vaccines. 2021; 9(3):259. https://doi.org/10.3390/vaccines9030259

Chicago/Turabian Style

Klimowicz-Bodys, Małgorzata D.; Płoneczka-Janeczko, Katarzyna; Czopowicz, Michał; Polak, Mirosław P.; Lachowicz-Wolak, Agnieszka; Rypuła, Krzysztof. 2021. "Antibody Response to a Live-Modified Virus Vaccine against Bovine Viral Diarrhoea in Dairy Cattle in a Field Trial" Vaccines 9, no. 3: 259. https://doi.org/10.3390/vaccines9030259

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