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Article

Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides

by
Patricia de León
1,†,
Rodrigo Cañas-Arranz
1,†,
Yago Saez
2,
Mar Forner
3,
Sira Defaus
3,
Dolores Cuadra
4,
María J. Bustos
1,
Elisa Torres
1,
David Andreu
3,
Esther Blanco
5,
Francisco Sobrino
1,* and
Sabine E. Hammer
6,*
1
Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), 28049 Madrid, Spain
2
Computer Science Department, Universidad Carlos III of Madrid, Leganés, 28911 Madrid, Spain
3
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
4
Computer Science Department, Universidad Rey Juan Carlos, 28933 Móstoles, Spain
5
Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain
6
Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria
*
Authors to whom correspondence should be addressed.
†
The authors contributed equally to this manuscript.
Vaccines 2020, 8(3), 513; https://doi.org/10.3390/vaccines8030513
Submission received: 25 June 2020 / Revised: 15 August 2020 / Accepted: 1 September 2020 / Published: 8 September 2020
(This article belongs to the Special Issue Evaluation of Vaccine Immunogenicity)
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Abstract

Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major FMDV antigenic B-cell site in VP1 protein, are covalently linked to heterotypic T-cell epitopes from 3A and/or 3D proteins, and elicited consistent levels of neutralizing antibodies and IFN-γ-producing cells in pigs. To address the contribution of the highly polymorphic nature of the porcine MHC (SLA, swine leukocyte antigen) on the immunogenicity of B2T dendrimers, low-resolution (Lr) haplotyping was performed. We looked for possible correlations between particular Lr haplotypes with neutralizing antibody and T-cell responses induced by B2T peptides. In this study, 63 pigs immunized with B2T dendrimers and 10 non-immunized (control) animals are analyzed. The results reveal a robust significant correlation between SLA class-II Lr haplotypes and the T-cell response. Similar correlations of T-cell response with SLA class-I Lr haplotypes, and between B-cell antibody response and SLA class-I and SLA class-II Lr haplotypes, were only found when the sample was reduced to animals with Lr haplotypes represented more than once. These results support the contribution of SLA class-II restricted T-cells to the magnitude of the T-cell response and to the antibody response evoked by the B2T dendrimers, being of potential value for peptide vaccine design against FMDV.
Keywords: swine; foot-and-mouth disease virus; dendrimer peptide; swine leukocyte antigen; SLA polymorphism; adaptive immunity; vaccine; protection swine; foot-and-mouth disease virus; dendrimer peptide; swine leukocyte antigen; SLA polymorphism; adaptive immunity; vaccine; protection

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MDPI and ACS Style

de León, P.; Cañas-Arranz, R.; Saez, Y.; Forner, M.; Defaus, S.; Cuadra, D.; Bustos, M.J.; Torres, E.; Andreu, D.; Blanco, E.; et al. Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides. Vaccines 2020, 8, 513. https://doi.org/10.3390/vaccines8030513

AMA Style

de León P, Cañas-Arranz R, Saez Y, Forner M, Defaus S, Cuadra D, Bustos MJ, Torres E, Andreu D, Blanco E, et al. Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides. Vaccines. 2020; 8(3):513. https://doi.org/10.3390/vaccines8030513

Chicago/Turabian Style

de León, Patricia, Rodrigo Cañas-Arranz, Yago Saez, Mar Forner, Sira Defaus, Dolores Cuadra, María J. Bustos, Elisa Torres, David Andreu, Esther Blanco, and et al. 2020. "Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides" Vaccines 8, no. 3: 513. https://doi.org/10.3390/vaccines8030513

APA Style

de León, P., Cañas-Arranz, R., Saez, Y., Forner, M., Defaus, S., Cuadra, D., Bustos, M. J., Torres, E., Andreu, D., Blanco, E., Sobrino, F., & Hammer, S. E. (2020). Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides. Vaccines, 8(3), 513. https://doi.org/10.3390/vaccines8030513

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