Next Article in Journal
Hepatitis B Seroprevalence in the Pediatric and Adolescent Population of Florence (Italy): An Update 27 Years after the Implementation of Universal Vaccination
Previous Article in Journal
Health Literacy, Vaccine Confidence and Influenza Vaccination Uptake among Nursing Home Staff: A Cross-Sectional Study Conducted in Tuscany
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Vaccines
Volume 8
Issue 2
10.3390/vaccines8020155
vaccines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines

by
John Benest
1,*,
Sophie Rhodes
1,
Sara Afrough
2,
Thomas Evans
2 and
Richard White
1
1
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
2
Vaccitech Ltd., The Schrodinger Building, Heatley Road, The Oxford Science Park, Oxford OX4 4GE, UK
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(2), 155; https://doi.org/10.3390/vaccines8020155
Submission received: 6 February 2020 / Revised: 20 March 2020 / Accepted: 26 March 2020 / Published: 30 March 2020
(This article belongs to the Section Vaccine Design, Development, and Delivery)
Browse Figures
Review Reports Versions Notes

Abstract

Vaccine dose-response curves can follow both saturating and peaking shapes. Dose-response curves for adenoviral vector vaccines have not been systematically described. In this paper, we explore the dose-response shape of published adenoviral animal and human studies. Where data were informative, dose-response was approximately five times more likely to be peaking than saturating. There was evidence that host species and response type may be sufficient for prediction of dose-response curve shape. Dose-response curve shape prediction could decrease clinical trial costs, accelerating the development of life-saving vaccines.
Keywords: dosing; dose-response; adenovirus-vectored vaccines; dose dynamics dosing; dose-response; adenovirus-vectored vaccines; dose dynamics

Share and Cite

MDPI and ACS Style

Benest, J.; Rhodes, S.; Afrough, S.; Evans, T.; White, R. Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines. Vaccines 2020, 8, 155. https://doi.org/10.3390/vaccines8020155

AMA Style

Benest J, Rhodes S, Afrough S, Evans T, White R. Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines. Vaccines. 2020; 8(2):155. https://doi.org/10.3390/vaccines8020155

Chicago/Turabian Style

Benest, John, Sophie Rhodes, Sara Afrough, Thomas Evans, and Richard White. 2020. "Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines" Vaccines 8, no. 2: 155. https://doi.org/10.3390/vaccines8020155

APA Style

Benest, J., Rhodes, S., Afrough, S., Evans, T., & White, R. (2020). Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines. Vaccines, 8(2), 155. https://doi.org/10.3390/vaccines8020155

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop