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Evaluation of Pneumococcal Surface Protein A as a Vaccine Antigen against Secondary Streptococcus pneumoniae Challenge during Influenza A Infection

Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
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Vaccines 2019, 7(4), 146; https://doi.org/10.3390/vaccines7040146
Received: 22 July 2019 / Revised: 27 September 2019 / Accepted: 2 October 2019 / Published: 11 October 2019
(This article belongs to the Section Vaccines against Infectious Diseases)
Secondary bacterial pneumonia is responsible for significant morbidity and mortality during seasonal and pandemic influenza. Due to the unpredictability of influenza A virus evolution and the time-consuming process of manufacturing strain-specific influenza vaccines, recent efforts have been focused on developing anti-Streptococcus pneumoniae immunity to prevent influenza-related illness and death. Bacterial vaccination to prevent viral-bacterial synergistic interaction during co-infection is a promising concept that needs further investigation. Here, we show that immunization with pneumococcal surface protein A (PspA) fully protects mice against low-dose, but not high-dose, secondary bacterial challenge using a murine model of influenza A virus-S. pneumoniae co-infection. We further show that immunization with PspA is more broadly protective than the pneumococcal conjugate vaccine (Prevnar). These results demonstrate that PspA is a promising vaccine target that can provide protection against a physiologically relevant dose of S. pneumoniae following influenza infection. View Full-Text
Keywords: influenza-pneumococcal co-infection; pneumococcal vaccination; pneumococcal surface protein A; Streptococcus pneumoniae; Prevnar influenza-pneumococcal co-infection; pneumococcal vaccination; pneumococcal surface protein A; Streptococcus pneumoniae; Prevnar
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Roberts, S.; Williams, C.M.; Salmon, S.L.; Bonin, J.L.; Metzger, D.W.; Furuya, Y. Evaluation of Pneumococcal Surface Protein A as a Vaccine Antigen against Secondary Streptococcus pneumoniae Challenge during Influenza A Infection. Vaccines 2019, 7, 146.

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