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Vaccines 2018, 6(3), 36; https://doi.org/10.3390/vaccines6030036

The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses

1
Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305, USA
2
Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
*
Author to whom correspondence should be addressed.
Received: 27 May 2018 / Revised: 25 June 2018 / Accepted: 26 June 2018 / Published: 29 June 2018
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Abstract

Recent studies have revealed multiple roles for Fc gamma receptors (FcγRs) in broad immunity against influenza viruses. Activating FcγR pathways can be harnessed to confer protection mediated by non-neutralizing anti-HA IgGs and to increase the potency of broadly neutralizing anti-HA IgGs and of anti-NA IgGs. Separate FcγR pathways can be targeted to enhance the breadth of antibody responses elicited by seasonal influenza virus vaccines. Here, we review the current understanding of FcγR pathways in broad influenza immunity and suggest mechanisms to bypass FcγR signaling heterogeneity among people that arises from distinctions in structural repertoires of IgG Fc domains. View Full-Text
Keywords: universal influenza vaccine; sialylation; Fc glycan; afucosylation; Fc receptors universal influenza vaccine; sialylation; Fc glycan; afucosylation; Fc receptors
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Thulin, N.K.; Wang, T.T. The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses. Vaccines 2018, 6, 36.

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