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Vaccines 2018, 6(3), 37; https://doi.org/10.3390/vaccines6030037

Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

1
Jenner Institute, University of Oxford, Oxford OX3 7BN, UK
2
Qatar Foundation, Doha, Qatar
3
Inselspital, Universitatsklinik RIA, Immunologie, 3010 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Received: 11 May 2018 / Revised: 21 June 2018 / Accepted: 28 June 2018 / Published: 2 July 2018
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Abstract

Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system. View Full-Text
Keywords: virus-like particle (VLP); innate immune system; adaptive immune system; Toll-like receptor (TLR) virus-like particle (VLP); innate immune system; adaptive immune system; Toll-like receptor (TLR)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mohsen, M.O.; Gomes, A.C.; Vogel, M.; Bachmann, M.F. Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System. Vaccines 2018, 6, 37.

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