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Vaccines 2016, 4(4), 46;

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Author to whom correspondence should be addressed.
Academic Editor: Massimo Zollo
Received: 27 August 2016 / Revised: 1 November 2016 / Accepted: 25 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Mechanisms of Tumor Escape from Host Immunity)
Full-Text   |   PDF [1200 KB, uploaded 6 December 2016]   |  


When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates “metabolic checkpoints” upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME. View Full-Text
Keywords: T cell; metabolism; immunotherapy; cancer; tumor microenvironment; metabolic checkpoints T cell; metabolism; immunotherapy; cancer; tumor microenvironment; metabolic checkpoints

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Scharping, N.E.; Delgoffe, G.M. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines 2016, 4, 46.

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