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Vaccines 2016, 4(4), 33;

Influenza and Memory T Cells: How to Awake the Force

Medical Biotechnology Center, VIB, Ghent 9000, Belgium
Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium
Author to whom correspondence should be addressed.
Received: 18 July 2016 / Accepted: 27 September 2016 / Published: 13 October 2016
(This article belongs to the Special Issue T Cell Memory to Vaccination)
Full-Text   |   PDF [1163 KB, uploaded 13 October 2016]   |  


Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals. The past few years, the importance of cellular immunity, and especially memory T cells, in long-lived protection against influenza virus has become clear. To overcome the shortcomings of current influenza vaccines, eliciting both humoral and cellular immunity is imperative. Today, several new vaccines such as infection-permissive and recombinant T cell inducing vaccines, are being developed and show promising results. These vaccines will allow us to stay several steps ahead of the constantly evolving influenza virus. View Full-Text
Keywords: influenza; vaccines; cellular immunity; memory T cells influenza; vaccines; cellular immunity; memory T cells

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Spitaels, J.; Roose, K.; Saelens, X. Influenza and Memory T Cells: How to Awake the Force. Vaccines 2016, 4, 33.

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