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Vaccines 2015, 3(3), 638-661;

Small Wonders—The Use of Nanoparticles for Delivering Antigen

School of Applied Sciences, RMIT University, P.O. Box 71 Bundoora, Victoria 3083, Australia
Author to whom correspondence should be addressed.
Academic Editor: Vasso Apostolopoulos
Received: 18 May 2015 / Revised: 15 July 2015 / Accepted: 31 July 2015 / Published: 10 August 2015
(This article belongs to the Special Issue Vaccine Delivery)
Full-Text   |   PDF [1429 KB, uploaded 10 August 2015]   |  


Despite the discovery of many potential antigens for subunit vaccines, universal protection is often lacking due to the limitations of conventional delivery methods. Subunit vaccines primarily induce antibody-mediated humoral responses, whereas potent antigen-specific cellular responses are required for prevention against some pathogenic infections. Nanoparticles have been utilised in nanomedicine and are promising candidates for vaccine or drug delivery. Nanoparticle vehicles have been demonstrated to be efficiently taken up by dendritic cells and induce humoral and cellular responses. This review provides an overview of nanoparticle vaccine development; in particular, the preparation of nanoparticles using a templating technique is highlighted, which would alleviate some of the disadvantages of existing nanoparticles. We will also explore the cellular fate of nanoparticle vaccines. Nanoparticle-based antigen delivery systems have the potential to develop new generation vaccines against currently unpreventable infectious diseases. View Full-Text
Keywords: nanoparticle; antigen delivery; templating system; adjuvant nanoparticle; antigen delivery; templating system; adjuvant

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Taki, A.; Smooker, P. Small Wonders—The Use of Nanoparticles for Delivering Antigen. Vaccines 2015, 3, 638-661.

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