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Vaccines
Volume 14
Issue 5
10.3390/vaccines14050449
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Study Protocol

The Maternal Vaccine Study Protocol: A Victorian Cohort Study Evaluating Infant and Childhood Safety and Health and Developmental Outcomes After Vaccination Against Respiratory Viruses in Pregnancy

by
Rachael Purcell
1,2,3,*,
Margie Danchin
2,4,5,
Nigel W. Crawford
2,5,6,
Eric Zhao
1,3,
Ashleigh Rak
4,
Michelle L. Giles
7,8 and
Jim Buttery
1,2,3
1
Epidemiology Informatics, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia
2
Department of Paediatrics, The University of Melbourne, Melbourne, VIC 3010, Australia
3
Centre for Health Analytics, The Royal Children’s Hospital, Parkville, VIC 3052, Australia
4
Vaccine Trials and Uptake Group, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia
5
Department of General Medicine, Royal Children’s Hospital, Melbourne, VIC 3052, Australia
6
SAEFVIC, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia
7
Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC 3168, Australia
8
Department of Infectious Diseases, The University of Melbourne, Melbourne, VIC 3052, Australia
*
Author to whom correspondence should be addressed.
Vaccines 2026, 14(5), 449; https://doi.org/10.3390/vaccines14050449
Submission received: 28 April 2026 / Revised: 14 May 2026 / Accepted: 15 May 2026 / Published: 18 May 2026
(This article belongs to the Section Vaccines and Public Health)
Versions Notes

Abstract

Objectives: Changes in public policy are eroding vaccine confidence. Previously accepted peer-reviewed evidence around vaccination and developmental outcomes for children is being questioned. Robust, methodologically sound safety data are more needed than ever to maintain consumer confidence. Establishing further safety data on infant health, development, and allergies after COVID-19 and influenza vaccination in pregnancy may improve confidence and acceptance. Methods: This is a state-wide multi-centre prospective cohort study conducted as a sub-study of the Generation Victoria birth cohort. It will examine the risk difference for infant health, developmental, and allergy outcomes between groups of mother–baby pairs who will be examined according to exposure (vaccination against a respiratory virus during pregnancy) and comparator (no vaccination against a respiratory virus). Results: Data contributing to the analysis include GenV-collected developmental, health, and allergy outcomes to 12 months of age, as well as data from state-wide linked datasets. Conclusions: This linked-data longitudinal study will provide information on health, allergy, and developmental outcomes for infants in the first year of life after influenza and COVID-19 vaccination during pregnancy. Implications for Public Health: The reporting of developmental data will be a new contribution to knowledge around outcomes after vaccination during pregnancy.
Keywords: maternal vaccination; pregnancy; vaccine; infant health; development; allergy maternal vaccination; pregnancy; vaccine; infant health; development; allergy

Share and Cite

MDPI and ACS Style

Purcell, R.; Danchin, M.; Crawford, N.W.; Zhao, E.; Rak, A.; Giles, M.L.; Buttery, J. The Maternal Vaccine Study Protocol: A Victorian Cohort Study Evaluating Infant and Childhood Safety and Health and Developmental Outcomes After Vaccination Against Respiratory Viruses in Pregnancy. Vaccines 2026, 14, 449. https://doi.org/10.3390/vaccines14050449

AMA Style

Purcell R, Danchin M, Crawford NW, Zhao E, Rak A, Giles ML, Buttery J. The Maternal Vaccine Study Protocol: A Victorian Cohort Study Evaluating Infant and Childhood Safety and Health and Developmental Outcomes After Vaccination Against Respiratory Viruses in Pregnancy. Vaccines. 2026; 14(5):449. https://doi.org/10.3390/vaccines14050449

Chicago/Turabian Style

Purcell, Rachael, Margie Danchin, Nigel W. Crawford, Eric Zhao, Ashleigh Rak, Michelle L. Giles, and Jim Buttery. 2026. "The Maternal Vaccine Study Protocol: A Victorian Cohort Study Evaluating Infant and Childhood Safety and Health and Developmental Outcomes After Vaccination Against Respiratory Viruses in Pregnancy" Vaccines 14, no. 5: 449. https://doi.org/10.3390/vaccines14050449

APA Style

Purcell, R., Danchin, M., Crawford, N. W., Zhao, E., Rak, A., Giles, M. L., & Buttery, J. (2026). The Maternal Vaccine Study Protocol: A Victorian Cohort Study Evaluating Infant and Childhood Safety and Health and Developmental Outcomes After Vaccination Against Respiratory Viruses in Pregnancy. Vaccines, 14(5), 449. https://doi.org/10.3390/vaccines14050449

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