Next Article in Journal
Duration of COVID-19 mRNA Vaccine Effectiveness against Severe Disease
Previous Article in Journal
NK Cell-Based Immunotherapy in Colorectal Cancer
 
 
Communication

Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population

1
Department of Social and Environmental Medicine, School of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
2
Department of Preventive Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
3
Division of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
4
Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
5
Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 840-8501, Japan
6
SOUSEIKAI Medical Group, Clinical Epidemiology Research Center, Medical Co., LTA, 3-6-1 Kashii-Teriha, Higashi-Ku, Fukuoka 813-0017, Japan
*
Author to whom correspondence should be addressed.
Current address: National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan.
Academic Editor: James Galloway
Vaccines 2022, 10(7), 1035; https://doi.org/10.3390/vaccines10071035
Received: 20 May 2022 / Revised: 19 June 2022 / Accepted: 22 June 2022 / Published: 28 June 2022
(This article belongs to the Special Issue Research on Immune Response and Vaccines)
Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that the most prevalent polymorphism of the aldehyde dehydrogenase 2 gene (ALDH2), rs671, may be associated with an attenuated immune system. To test the inverse relationship between rs671 and antibody production after COVID-19 vaccination, the levels of anti-SARS-CoV-2 Spike protein S1 subunit (S1) IgG were repeatedly measured for four months before and after vaccination with BNT162b2 or mRNA-1273, in 88 Japanese workers and students (including 45 females, aged 21–56 years, with an rs671 variant allele frequency of 0.3). The mixed model including fixed effects of the vaccine type, weeks post vaccination (categorical variable), sex, age, height, smoking status, ethanol intake, exercise habit, perceived stress, steroid use, allergic diseases, and dyslipidemia, indicated an inverse association between log-transformed anti-S1 IgG levels and the number of rs671 variant alleles (partial regression coefficient = −0.15, p = 0.002). Our study indicated for the first time that the variant allele of ALDH2, rs671, is associated with the attenuated immunogenicity of COVID-19 mRNA vaccines. Our finding may provide a basis for personalized disease prevention based on a genetic polymorphism that is prevalent among East Asians. View Full-Text
Keywords: ALDH2; rs671; COVID-19; vaccine; immunogenicity ALDH2; rs671; COVID-19; vaccine; immunogenicity
Show Figures

Figure 1

MDPI and ACS Style

Matsumoto, A.; Hara, M.; Ashenagar, M.S.; Tokiya, M.; Sawada, T.; Iwasaka, C.; Furukawa, T.; Kitagawa, K.; Miyake, Y.; Hirota, Y. Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population. Vaccines 2022, 10, 1035. https://doi.org/10.3390/vaccines10071035

AMA Style

Matsumoto A, Hara M, Ashenagar MS, Tokiya M, Sawada T, Iwasaka C, Furukawa T, Kitagawa K, Miyake Y, Hirota Y. Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population. Vaccines. 2022; 10(7):1035. https://doi.org/10.3390/vaccines10071035

Chicago/Turabian Style

Matsumoto, Akiko, Megumi Hara, Mohammad Said Ashenagar, Mikiko Tokiya, Takeshi Sawada, Chiharu Iwasaka, Takuma Furukawa, Kyoko Kitagawa, Yasunobu Miyake, and Yoshio Hirota. 2022. "Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population" Vaccines 10, no. 7: 1035. https://doi.org/10.3390/vaccines10071035

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop