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Brief Report

Identification of Potential SARS-CoV-2 CD8+ T Cell Escape Mutants

1
Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, VIC 3010, Australia
2
Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China
3
Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia
4
Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editors: Soo-Hong Lee, Hansoo Park, Jagathesh Chandra Rajendran and K.S Jaganathan
Vaccines 2022, 10(4), 542; https://doi.org/10.3390/vaccines10040542
Received: 14 February 2022 / Revised: 19 March 2022 / Accepted: 29 March 2022 / Published: 31 March 2022
(This article belongs to the Special Issue The COVID Vaccine)
Memory SARS-CoV-2-specific CD8+ T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be weakened by genetic mutations in future SARS-CoV-2 variants that lead to widespread T cell escape. The capacity for SARS-CoV-2 mutations to escape memory T cell responses requires comprehensive experimental investigation, though this is prohibited by the large number of SARS-CoV-2 mutations that have been observed. To guide targeted experimental studies, here we provide a screened list of potential SARS-CoV-2 T cell escape mutants. These mutants are identified as candidates for T cell escape as they lie within CD8+ T cell epitopes that are commonly targeted in individuals and are predicted to abrogate HLA–peptide binding. View Full-Text
Keywords: SARS-CoV-2; COVID-19; CD8+ T cell epitopes; immunoprevalent; immune escape; mutations; variants of concern SARS-CoV-2; COVID-19; CD8+ T cell epitopes; immunoprevalent; immune escape; mutations; variants of concern
MDPI and ACS Style

Ahmed, S.F.; Sohail, M.S.; Quadeer, A.A.; McKay, M.R. Identification of Potential SARS-CoV-2 CD8+ T Cell Escape Mutants. Vaccines 2022, 10, 542. https://doi.org/10.3390/vaccines10040542

AMA Style

Ahmed SF, Sohail MS, Quadeer AA, McKay MR. Identification of Potential SARS-CoV-2 CD8+ T Cell Escape Mutants. Vaccines. 2022; 10(4):542. https://doi.org/10.3390/vaccines10040542

Chicago/Turabian Style

Ahmed, Syed F., Muhammad S. Sohail, Ahmed A. Quadeer, and Matthew R. McKay. 2022. "Identification of Potential SARS-CoV-2 CD8+ T Cell Escape Mutants" Vaccines 10, no. 4: 542. https://doi.org/10.3390/vaccines10040542

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