A Case of Atypical Unilateral Optic Neuritis Following BNT162b2 mRNA COVID-19 Vaccination
Abstract
:1. Background
2. Case Presentation
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author (Year) | Age (Sex) | Medical History | Clinical Presentation | Diagnosis | Vaccine | Time between Vaccination and Symptoms | Treatment | Final Visual Acuity | |
---|---|---|---|---|---|---|---|---|---|
1 | Ayman G Elnahry (2021) [11] | 69 (female) | None | Bilateral vision loss | Bilateral optic neuritis | mRNA (Pfizer-BioNTech) 2nd dose | 16 days | 1000 mg/day intravenous methylprednisolone (IVMP) for 5 days, | Stable |
32 (female) | None | Blurred vision OS | Optic neuritis OS | Viral vector (Oxford–AstraZeneca) 1st dose | 5 days | 1000 mg/day IVMP for 3 days | 20/20 | ||
2 | Henrique M. Leber (2021) [16] | 32 (female) | None | Vision loss and pain OS | Bilateral optic neuritis and thyroiditis | Inactivated (Sinovac) 2nd dose | 12 h | 1000 mg/day IVMP for 5 days | 20/20 OD 20/25 OS |
3 | Rika Tsukii (2021) [17] | 55 (female) | None | Visual field disturbance OD | Non-arteritic anterior ischemic optic neuropathy (NA-AION) OD | mRNA (Pfizer-BioNTech) 1st dose | 7 days | No treatment | 20/20 |
4 | Valentina Arnao (2022) [14] | Middle-age (female) | None | Bilateral blurred vision and pain | Bilateral optic neuritis | Viral vector (Oxford–AstraZeneca) 1st dose | 14 days | 1000 mg/day IVMP for 5 days | Recovered |
5 | Jiajun Wang (2022) [12] | 21 (female) | None | Blurred vision OD with ocular rotation pain | Optic neuritis OD | Inactivated (Sinopharm) 2nd dose | 3 weeks | 800 mg/day IVMP for 3 days | 20/20 |
38 (female) | None | Blurred vision OD | Optic neuritis OD | Inactivated (Sinopharm) 1st dose | 3 weeks | 1000 mg/day IVMP for 3 days | 20/20 | ||
6 | Madhurima Roy (2022) [13] | 27 (female) | None | Progressive blurring of vision OS | Optic neuritis OS | Viral vector (Covishield) 1st dose | 9 days | 1000 mg/day IVMP for 3 days | 20/40 |
48 (female) | None | Painless gradual diminution of vision OS | Optic neuritis OS | Viral vector (Covishield) 2nd dose | 5 days | 1000 mg/day IVMP for 3 days | 20/30 | ||
40 (male) | None | Blurring vision in both eyes | Bilateral optic neuritis | Viral vector (Covishield) 1st dose | 12 days | Steroid therapy | 20/30 OD 20/40 OS | ||
7 | Mahsa Khayat-Khoei (2022) [7] | 26 (female) | None | Blurred vision and pain OD | New onset relapsing-remitting multiple sclerosis (RRMS) | mRNA (Moderna) 2nd dose | 14 days | 1000 mg/day IVMP for 5 days | - |
64 (male) | RRMS | Vision changes and pain OD | Multiple sclerosis (MS) exacerbation | mRNA (Pfizer-BioNTech) 2nd dose | 1 day | 1000 mg/day IVMP for 3 days | - | ||
33 (male) | none | Blurred vision OS | New onset RRMS | mRNA (Pfizer-BioNTech) 2nd dose | 1 day | 1000 mg/day IVMP for 3 days | - | ||
48 (female) | clinically isolated demyelinating syndrome (CIS) | Pain OD, Lhermitte’s, balance/gait | Conversion from CIS to RRMS | mRNA (Pfizer-BioNTech) 1st dose | 15 days | 1000 mg/day IVMP for 3 days | - | ||
8 | Christian García-Estrada (2022) [15] | 19 (female) | None | Vision loss and pain OS | Optic neuritis OS | Viral vector (Janssen) 1st dose | 1 week | 1000 mg/day IVMP for 5 days | 20/20 |
9 | Yelda Yıldız Tascı (2022) [8] | 32 (male) | Graves’ disease | Ocular pain and blurred vision OD | Neuromyelitis optica spectrum disorders (NMOSD) OD | Inactivated (Sinovac) 1st dose | 14 days | 1000 mg/day IVMP for 5 days | 20/20 |
10 | Sai A Nagaratnam (2022) [10] | 36 (female) | None | Bilateral vision loss and subjective color desaturation, painful eye movements and fatigue | Bilateral optic neuritis | Viral vector (Oxford–AstraZeneca ChAdOx1) 1st dose | 14 days | 1000 mg/day IVMP for 3 days | 20/16 OD 20/20 OS |
11 | Bader Shirah (2022) [9] | 31 (female) | Systemic lupus erythematosus (SLE) | Painful eye movements and blurred vision OS | NMOSD OS | mRNA (Pfizer-BioNTech) 2nd dose | 14 days | 1000 mg/day IVMP for 2 days | - |
12 | Wen-Yun Lin (2022) [18] | 61 (female) | Hypertension and hyperlipidemia | Blurred vision OS | NA-AION OS | Viral vector (Oxford–AstraZeneca ChAdOx1) 2nd dose | 7 days | Oral prednisolone 60 mg/day | 20/80 |
13 | Abdelrahman M Elhusseiny (2022) [19] | 51 (male) | None | Vision loss OS | NA-AION OS | mRNA (Pfizer-BioNTech) 2nd dose | 1 day | Oral prednisone over 1 month | 20/400 |
14 | Sonia Valsero Franco (2022) [20] | 53 (male) | None | Bilateral vision loss | Suspected bilateral NA-AION | mRNA (Pfizer-BioNTech) 1st dose OD mRNA (Pfizer-BioNTech) 2nd dose OS | 7 days 10 days | Acetazolamide 750 mg/day | 20/20 OD 20/40 OS |
65 (male) | Arterial hypertension | Blurred vision OD | Suspected NA-AION OD | mRNA (Pfizer-BioNTech) 1st dose | 12 days | No treatment | 20/200 | ||
15 | Snezhana Murgova (2022) [21] | 45 (male) | Arterial hypertension | Visual disturbance OD | NA-AION OD | mRNA (Pfizer-BioNTech) 2nd dose | 10 days | Vasodilators and anti-platelet therapy | 20/20 |
16 | Seung Ah Chung (2022) [22] | 65 (female) | None | Sudden inferior visual field loss OD | NA-AION OD | Viral vector (Oxford–AstraZeneca ChAdOx1) 2nd dose | 15 days | 1000 mg/day IVMP for 3 days | 20/200 |
17 | Ilay Caliskan (2022) [23] | 43 (female) | None | Blurred vision and movement-associated pain OD | NMOSD OD | mRNA (Pfizer-BioNTech) 2nd dose | 1 day | IVMP and plasma exchange | - |
18 | Srinivasan Sanjay (2022) [24] | 50s (Female) | Non-arteritic anterior ischaemic optic neuropathy (NA-AION) OD | Vision loss OS | NA-AION OS | Viral vector (Covishield) 1st dose | 4 days | Oral aspirin 75 mg for 1 month | 20/20 |
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Motegi, S.; Kanda, T.; Takeuchi, M. A Case of Atypical Unilateral Optic Neuritis Following BNT162b2 mRNA COVID-19 Vaccination. Vaccines 2022, 10, 1574. https://doi.org/10.3390/vaccines10101574
Motegi S, Kanda T, Takeuchi M. A Case of Atypical Unilateral Optic Neuritis Following BNT162b2 mRNA COVID-19 Vaccination. Vaccines. 2022; 10(10):1574. https://doi.org/10.3390/vaccines10101574
Chicago/Turabian StyleMotegi, Shuntaro, Takayuki Kanda, and Masaru Takeuchi. 2022. "A Case of Atypical Unilateral Optic Neuritis Following BNT162b2 mRNA COVID-19 Vaccination" Vaccines 10, no. 10: 1574. https://doi.org/10.3390/vaccines10101574