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Anti-SARS-CoV-2 IgG against the S Protein: A Comparison of BNT162b2, mRNA-1273, ChAdOx1 nCoV-2019 and Ad26.COV2.S Vaccines

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Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 87-100 Torun, Poland
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Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Torun, Poland
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Faculty of Mathematics and Computer Science, Nicolaus Copernicus University, 87-100 Torun, Poland
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Cancer Genetics Laboratory Ltd., 87-100 Torun, Poland
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Academic Research Center AKAMED Ltd., 87-100 Torun, Poland
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Polish-Japanese Academy of Information Technology, 02-008 Warszawa, Poland
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Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, Poland
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Department of Internal and Infectious Diseases, Provincial Infectious Disease Hospital, 85-067 Bydgoszcz, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Martin H. Bluth
Vaccines 2022, 10(1), 99; https://doi.org/10.3390/vaccines10010099
Received: 12 November 2021 / Revised: 28 December 2021 / Accepted: 7 January 2022 / Published: 10 January 2022
(This article belongs to the Topic Global Analysis of SARS-CoV-2 Serology)
Background: COVID-19 vaccines induce a differentiated humoral and cellular response, and one of the comparable parameters of the vaccine response is the determination of IgG antibodies. Materials and Methods: Concentrations of IgG anti-SARS-CoV-2 antibodies were analyzed at three time points (at the beginning of May, at the end of June and at the end of September). Serum samples were obtained from 954 employees of the Nicolaus Copernicus University in Toruń (a total of three samples each were obtained from 511 vaccinated participants). IgG antibody concentrations were determined by enzyme immunoassay. The statistical analysis included comparisons between vaccines, between convalescents and COVID-19 non-patients, between individual measurements and included the gender, age and blood groups of participants. Results: There were significant differences in antibody levels between mRNA and vector vaccines. People vaccinated with mRNA-1273 achieved the highest levels of antibodies, regardless of the time since full vaccination. People vaccinated with ChAdOx1 nCoV-2019 produced several times lower antibody levels compared to the mRNA vaccines, while the antibody levels were more stable. In the case of each of the vaccines, the factor having the strongest impact on the level and stability of the IgG antibody titers was previous SARS-CoV-2 infection. There were no significant correlations with age, gender and blood type. Summary: mRNA vaccines induce a stronger humoral response of the immune system with the fastest loss of antibodies over time. View Full-Text
Keywords: SARS-CoV-2; COVID-19; Pfizer/BioNTech; Oxford/AstraZeneca; Moderna; Janssen/Johnson & Johnson; vaccines; antibodies SARS-CoV-2; COVID-19; Pfizer/BioNTech; Oxford/AstraZeneca; Moderna; Janssen/Johnson & Johnson; vaccines; antibodies
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MDPI and ACS Style

Szczepanek, J.; Skorupa, M.; Goroncy, A.; Jarkiewicz-Tretyn, J.; Wypych, A.; Sandomierz, D.; Jarkiewicz-Tretyn, A.; Dejewska, J.; Ciechanowska, K.; Pałgan, K.; Rajewski, P.; Tretyn, A. Anti-SARS-CoV-2 IgG against the S Protein: A Comparison of BNT162b2, mRNA-1273, ChAdOx1 nCoV-2019 and Ad26.COV2.S Vaccines. Vaccines 2022, 10, 99. https://doi.org/10.3390/vaccines10010099

AMA Style

Szczepanek J, Skorupa M, Goroncy A, Jarkiewicz-Tretyn J, Wypych A, Sandomierz D, Jarkiewicz-Tretyn A, Dejewska J, Ciechanowska K, Pałgan K, Rajewski P, Tretyn A. Anti-SARS-CoV-2 IgG against the S Protein: A Comparison of BNT162b2, mRNA-1273, ChAdOx1 nCoV-2019 and Ad26.COV2.S Vaccines. Vaccines. 2022; 10(1):99. https://doi.org/10.3390/vaccines10010099

Chicago/Turabian Style

Szczepanek, Joanna, Monika Skorupa, Agnieszka Goroncy, Joanna Jarkiewicz-Tretyn, Aleksandra Wypych, Dorota Sandomierz, Aleksander Jarkiewicz-Tretyn, Joanna Dejewska, Karolina Ciechanowska, Krzysztof Pałgan, Paweł Rajewski, and Andrzej Tretyn. 2022. "Anti-SARS-CoV-2 IgG against the S Protein: A Comparison of BNT162b2, mRNA-1273, ChAdOx1 nCoV-2019 and Ad26.COV2.S Vaccines" Vaccines 10, no. 1: 99. https://doi.org/10.3390/vaccines10010099

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