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Article

SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population

by
Marwa O. Elgendy
1,2,
Ahmed O. El-Gendy
3,
Abdulaziz Ibrahim Alzarea
4,
Sarah Mahmoud
5,
Saad S. Alqahtani
6,7,
Alzhraa M. Fahmy
8,
Hesham R. El-Seedi
9,10,11,
Ahmed M. Sayed
12,
Ahmed D. Alatawi
4,
Mohamed E. A. Abdelrahim
13,* and
Abdullah S. Alanazi
4,14,*
1
Department of Clinical Pharmacy, Teaching Hospital of Faculty of Medicine, Beni-Suef University, Beni-Suef 62513, Egypt
2
Department of Clinical Pharmacy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt
3
Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62513, Egypt
4
Clinical Pharmacy Department, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia
5
Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62513, Egypt
6
Department of Clinical Pharmacy, Collage of Pharmacy, Jazan University, Jazan 82511, Saudi Arabia
7
Pharmacy Practice Research Unit, Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 82511, Saudi Arabia
8
Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62513, Egypt
9
Pharmacognosy Group, Department of Pharmaceutical Biosciences, BMC, Uppsala University, SE 751 24 Uppsala, Sweden
10
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
11
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
12
Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt
13
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62513, Egypt
14
Health Sciences Research Unit, Jouf University, Sakaka 72341, Saudi Arabia
 
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*
Authors to whom correspondence should be addressed.
Vaccines 2022, 10(1), 18; https://doi.org/10.3390/vaccines10010018
Submission received: 5 October 2021 / Revised: 19 December 2021 / Accepted: 21 December 2021 / Published: 24 December 2021
(This article belongs to the Special Issue The COVID Vaccine)
Versions Notes

Abstract

Vaccines are the solution to overcome SARS-CoV-2. This study aimed to determine the post-Sinopharm vaccine safety-profile and immunity through antibody titers. Data were collected using a structured questionnaire from Egyptian participants who received two doses of Sinopharm vaccine. Data were divided into three parts, the first and second parts were to detect participants’ post-first and second dose symptoms and practices, and the third for the results of IgG anti spike protein antibodies test and laboratory tests. Pain, redness, swelling at the injection site, headache, fatigue, and lethargy were the most common post-vaccine symptoms for both first and second doses. Most of the participants felt mild or no symptoms after vaccination. The symptoms started mostly during the first day post-vaccination and lasted for no more than two days. Forty-nine percent of the participants resulted in positive antibodies tests on day 18 post-vaccination. The average antibody level for vaccinated participants with past SARS-CoV-2 infection was much higher than that for non-past infected participants. These vaccines’ administration methods need to be reevaluated by changing the dose, dose interval, adding a third dose, or mixing it with other vaccines with different techniques to improve their protection rates. Further studies are required to validate this finding.
Keywords: Sinopharm vaccine; COVID-19; IgG; SARS-CoV-2; anti-spike; adverse effects Sinopharm vaccine; COVID-19; IgG; SARS-CoV-2; anti-spike; adverse effects

Share and Cite

MDPI and ACS Style

Elgendy, M.O.; El-Gendy, A.O.; Alzarea, A.I.; Mahmoud, S.; Alqahtani, S.S.; Fahmy, A.M.; El-Seedi, H.R.; Sayed, A.M.; Alatawi, A.D.; Abdelrahim, M.E.A.; et al. SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population. Vaccines 2022, 10, 18. https://doi.org/10.3390/vaccines10010018

AMA Style

Elgendy MO, El-Gendy AO, Alzarea AI, Mahmoud S, Alqahtani SS, Fahmy AM, El-Seedi HR, Sayed AM, Alatawi AD, Abdelrahim MEA, et al. SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population. Vaccines. 2022; 10(1):18. https://doi.org/10.3390/vaccines10010018

Chicago/Turabian Style

Elgendy, Marwa O., Ahmed O. El-Gendy, Abdulaziz Ibrahim Alzarea, Sarah Mahmoud, Saad S. Alqahtani, Alzhraa M. Fahmy, Hesham R. El-Seedi, Ahmed M. Sayed, Ahmed D. Alatawi, Mohamed E. A. Abdelrahim, and et al. 2022. "SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population" Vaccines 10, no. 1: 18. https://doi.org/10.3390/vaccines10010018

APA Style

Elgendy, M. O., El-Gendy, A. O., Alzarea, A. I., Mahmoud, S., Alqahtani, S. S., Fahmy, A. M., El-Seedi, H. R., Sayed, A. M., Alatawi, A. D., Abdelrahim, M. E. A., & Alanazi, A. S. (2022). SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population. Vaccines, 10(1), 18. https://doi.org/10.3390/vaccines10010018

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