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Open AccessArticle

Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study

1
Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
2
Department of Neurology and Pediatric Neurology, Iuliu Haţieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
3
Department of Medical Informatics and Biostatistics, Iuliu Haţieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
4
Clinical Rehabilitation Hospital, 400437 Cluj-Napoca, Romania
5
Department of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(6), 494; https://doi.org/10.3390/antiox9060494
Received: 14 May 2020 / Revised: 29 May 2020 / Accepted: 2 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue Oxidative Stress and Neurodegenerative Disorders)
Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients. Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. RNFL thickness was assessed for all subjects by the ocular coherence tomography spectral domain (OCT-SD). The oxidative stress parameter, namely nitric oxide (NOx), malondialdehyde (MDA), and total oxidative stress (TOS) were assessed. The antioxidant capacity of plasma was evaluated by assessing the level of catalase, and total anti-oxidative (TOS) capacity. Migraine severity was graded using the Migraine Disability Assessment Score (MIDAS) questionnaire. Results: All the oxidative stress parameters (NOx, MDA, and TOS) were significantly increased, and both parameters for anti-oxidative status were significantly decreased in the migraine group compared with the control group (p < 0.0001). Significant correlations with all the quadrants and different oxidative stress parameters were found, most involved being temporal quadrant. A significant positive correlation between catalase and macular RNFL thickness (inner ring, temporal quadrant) in migraine patients, for both eyes, was observed (p = 0.014 for the right eye and p = 0.12 for the left eye). Conclusion: The assessment of the oxidative stress/anti-oxidative balance together with RFLN thickness can constitute a promising method to evaluate the progression of the diseases. It can also contribute to the estimation of the efficiency of various therapies targeting oxidative stress and associated inflammation. View Full-Text
Keywords: retinal nerve fiber layer (RNFL) thickness; migraine; optical coherence tomography (OCT); oxidative stress retinal nerve fiber layer (RNFL) thickness; migraine; optical coherence tomography (OCT); oxidative stress
MDPI and ACS Style

Bulboacă, A.E.; Stănescu, I.C.; Bolboacă, S.D.; Bulboacă, A.C.; Bodizs, G.I.; Nicula, C.A. Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study. Antioxidants 2020, 9, 494.

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