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Open AccessReview

Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism

by David Mantle 1 and Alex Dybring 2,*
1
Pharma Nord (UK) Ltd., Telford Court, Morpeth, Northumberland NE61 2DB, UK
2
Pharma Nord (DK) ApS, Sadelmagervej 30-32, DK-7100 Vejle, Denmark
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(5), 386; https://doi.org/10.3390/antiox9050386
Received: 25 March 2020 / Revised: 24 April 2020 / Accepted: 30 April 2020 / Published: 5 May 2020
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q10 (CoQ10) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ10 supplements, with potential consequences for the use of such products in clinical trials. The purpose of the present review article is, therefore, to describe the various stages of exogenous CoQ10 metabolism, from its first ingestion, stomach transit, absorption from the small intestine into the lymphatic system, transport in blood, and access into cells. In particular, the importance of CoQ10 crystal dispersion in the initial formulation is emphasised, the absence of which reduces bioavailability by 75%. In addition, evidence comparing the relative bioavailability and efficacy of ubiquinone and ubiquinol forms of CoQ10 has been reviewed. View Full-Text
Keywords: coenzyme Q10; bioavailability; ubiquinone; ubiquinol; absorption; transport; cellular metabolism coenzyme Q10; bioavailability; ubiquinone; ubiquinol; absorption; transport; cellular metabolism
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Mantle, D.; Dybring, A. Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism. Antioxidants 2020, 9, 386.

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