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Review

Vitamin C and Cardiovascular Disease: An Update

1
Division of Cardiology, Department of Medicine, Institute of Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY 10461, USA
2
Department of Molecular Pharmacology, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein-Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, New York, NY 10461, USA
3
Department of Advanced Biomedical Sciences, “Federico II” University, 80131 Naples, Italy
4
International Translational Research and Medical Education (ITME), 80100 Naples, Italy
5
Department of Neuroscience, “Federico II” University, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Antioxidants 2020, 9(12), 1227; https://doi.org/10.3390/antiox9121227
Received: 5 October 2020 / Revised: 24 November 2020 / Accepted: 27 November 2020 / Published: 3 December 2020
(This article belongs to the Special Issue Free Radicals and Cardiovascular Diseases)
The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed. View Full-Text
Keywords: ascorbic acid; blood pressure; coronavirus; COVID–19; dietary supplements; drug formulations; endothelial dysfunction; GULO; heart failure; hypertension; infections; liposomes; oxidative stress; stroke; SVCT; vascular permeability; Vitamin C ascorbic acid; blood pressure; coronavirus; COVID–19; dietary supplements; drug formulations; endothelial dysfunction; GULO; heart failure; hypertension; infections; liposomes; oxidative stress; stroke; SVCT; vascular permeability; Vitamin C
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MDPI and ACS Style

Morelli, M.B.; Gambardella, J.; Castellanos, V.; Trimarco, V.; Santulli, G. Vitamin C and Cardiovascular Disease: An Update. Antioxidants 2020, 9, 1227. https://doi.org/10.3390/antiox9121227

AMA Style

Morelli MB, Gambardella J, Castellanos V, Trimarco V, Santulli G. Vitamin C and Cardiovascular Disease: An Update. Antioxidants. 2020; 9(12):1227. https://doi.org/10.3390/antiox9121227

Chicago/Turabian Style

Morelli, Marco B.; Gambardella, Jessica; Castellanos, Vanessa; Trimarco, Valentina; Santulli, Gaetano. 2020. "Vitamin C and Cardiovascular Disease: An Update" Antioxidants 9, no. 12: 1227. https://doi.org/10.3390/antiox9121227

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