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Article

Phaseolus vulgaris L. var. Venanzio Grown in Tuscany: Chemical Composition and In Vitro Investigation of Potential Effects on Colorectal Cancer

1
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
2
Department of Physical Sciences, Earth and Environment, University of Siena, Via Laterina 8, 53100 Siena, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2020, 9(12), 1181; https://doi.org/10.3390/antiox9121181
Received: 9 September 2020 / Revised: 13 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020
Phaseolus vulgaris L. (common bean) is a leguminous species that is an important dietary component due to its high content of proteins, unsaturated fatty acids, minerals, dietary fibers and vitamins. Due to the high content of polyphenols, several biological activities have been described for bean extracts, making it possible to include P. vulgaris among food with beneficial effects for human health. Moreover, more than 40,000 varieties of beans have been recognised with different nutraceutical properties, pointing out the importance of food biodiversity. In this work, we describe for the first time the chemical composition and biological activity of a newly recognized Italian variety of P. vulgaris grown in a restricted area of the Tuscany region and named “Fagiola di Venanzio”. Fagiola di Venanzio water extract is rich in proteins, sugars and polyphenols and displays antioxidant, anti-inflammatory and antiproliferative activities in in vitro assays on colon cancer cellular models. Our data indicate that this variety of P. vulgaris appears to be a promising source of bioactive compounds and encourage more in-depth studies to better elucidate the implications of its consumption for public health. View Full-Text
Keywords: Phaseulus vulgaris L.; biodiversity; nutraceuticals; oxidative stress; inflammation; functional food; COX-2; colon cancer Phaseulus vulgaris L.; biodiversity; nutraceuticals; oxidative stress; inflammation; functional food; COX-2; colon cancer
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MDPI and ACS Style

Finetti, F.; Biagi, M.; Ercoli, J.; Macrì, G.; Miraldi, E.; Trabalzini, L. Phaseolus vulgaris L. var. Venanzio Grown in Tuscany: Chemical Composition and In Vitro Investigation of Potential Effects on Colorectal Cancer. Antioxidants 2020, 9, 1181. https://doi.org/10.3390/antiox9121181

AMA Style

Finetti F, Biagi M, Ercoli J, Macrì G, Miraldi E, Trabalzini L. Phaseolus vulgaris L. var. Venanzio Grown in Tuscany: Chemical Composition and In Vitro Investigation of Potential Effects on Colorectal Cancer. Antioxidants. 2020; 9(12):1181. https://doi.org/10.3390/antiox9121181

Chicago/Turabian Style

Finetti, Federica, Marco Biagi, Jasmine Ercoli, Giulia Macrì, Elisabetta Miraldi, and Lorenza Trabalzini. 2020. "Phaseolus vulgaris L. var. Venanzio Grown in Tuscany: Chemical Composition and In Vitro Investigation of Potential Effects on Colorectal Cancer" Antioxidants 9, no. 12: 1181. https://doi.org/10.3390/antiox9121181

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