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Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

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Nanotechnology and Catalysis Research Centre (NANOCAT), Institute for Advanced Studies, University of Malaya, Kuala Lumpur 50603, Malaysia
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Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 0627, New Zealand
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Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
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Drug Design and Development Research Group, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
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School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1142, New Zealand
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Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 24; https://doi.org/10.3390/antiox9010024
Received: 20 November 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 26 December 2019
Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities. View Full-Text
Keywords: antioxidant; nanoparticles; nanoantioxidant; antioxidant delivery; nanocarrier; nanoencapsulation antioxidant; nanoparticles; nanoantioxidant; antioxidant delivery; nanocarrier; nanoencapsulation
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MDPI and ACS Style

Khalil, I.; Yehye, W.A.; Etxeberria, A.E.; Alhadi, A.A.; Dezfooli, S.M.; Julkapli, N.B.M.; Basirun, W.J.; Seyfoddin, A. Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications. Antioxidants 2020, 9, 24.

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