Myrciaria tenella (DC.) O. Berg (Myrtaceae) Leaves as a Source of Antioxidant Compounds
AbstractMyrciaria species are widely studied to identify their chemical composition and evaluate their biological activity. Since evidence supporting the potential antioxidant and antiproliferative activity of Myrciaria tenella is lacking, the aim of this work was to evaluate these activities in six different leaf extracts: hexane (CHE), chloroform (CCE), ethanolic (CEE), methanolic (CME), aqueous final (CFAE), and only aqueous (CAE). The presence of phenolic compounds, tannin, saponin, and ursolic acid was determined by thin layer chromatography (TLC). CEE, CME, and CFAE showed in vitro antioxidant activity at the initiation, propagation, and termination stages of oxidative damage. Moreover, no toxicity was observed in the 3T3 non-cancerous cell line. On the other hand, all extracts promoted cell death in the tumor cell lines human cervical adenocarcinoma cell line (HeLa) and human stomach gastric adenocarcinoma cell line (AGS). Based on these results, the effect of CEE on the AGS cell line was analyzed using flow cytometry, and necrosis and late apoptosis were observed. Finally, the Caenorhabditis elegans model showed that CEE was able to reduce the basal reactive oxygen species (ROS) level. Ultra-performance liquid chromatography (UPLC) analysis showed rutin as the major compound in CEE. Therefore, Myrciaria tenella fresh leaves may be potential sources of molecules possessing antioxidant and antiproliferative activities. View Full-Text
Share & Cite This Article
Ribeiro, A.R.C.; Cordeiro, M.L.S.; Silva, L.M.P.; Cadavid, C.O.M.; Caland, R.B.O.; Fernandes-Negreiros, M.M.; Queiroz, M.F.; Barbosa, J.S.; Aragão, C.F.S.; Zucolotto, S.M.; Oliveira, R.P.; Rocha, H.A.O.; Scortecci, K.C. Myrciaria tenella (DC.) O. Berg (Myrtaceae) Leaves as a Source of Antioxidant Compounds. Antioxidants 2019, 8, 310.
Ribeiro ARC, Cordeiro MLS, Silva LMP, Cadavid COM, Caland RBO, Fernandes-Negreiros MM, Queiroz MF, Barbosa JS, Aragão CFS, Zucolotto SM, Oliveira RP, Rocha HAO, Scortecci KC. Myrciaria tenella (DC.) O. Berg (Myrtaceae) Leaves as a Source of Antioxidant Compounds. Antioxidants. 2019; 8(8):310.Chicago/Turabian Style
Ribeiro, Ana R.C.; Cordeiro, Maria L.S.; Silva, Larissa M.P.; Cadavid, Cesar O.M.; Caland, Ricardo B.O.; Fernandes-Negreiros, Marília M.; Queiroz, Moacir F.; Barbosa, Jefferson S.; Aragão, Cicero F.S.; Zucolotto, Silvana M.; Oliveira, Riva P.; Rocha, Hugo A.O.; Scortecci, Kátia C. 2019. "Myrciaria tenella (DC.) O. Berg (Myrtaceae) Leaves as a Source of Antioxidant Compounds." Antioxidants 8, no. 8: 310.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.