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Open AccessArticle

Crosstalk Between Adipokines and Paraoxonase 1: A New Potential Axis Linking Oxidative Stress and Inflammation

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Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy
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Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, 44121 Ferrara, Italy
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Department of Biomedical and Specialist Surgical Sciences and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy
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Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, 44121 Ferrara, Italy
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Department of Medical Sciences, Internal Medicine and CardioRespiratory Section, University of Ferrara, 44121 Ferrara, Italy
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Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics-Ctr. Hemostasis & Thrombosis, University of Ferrara, 44121 Ferrara, Italy
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University Center for Studies on Gender Medicine, University of Ferrara, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(8), 287; https://doi.org/10.3390/antiox8080287
Received: 8 July 2019 / Revised: 29 July 2019 / Accepted: 2 August 2019 / Published: 6 August 2019
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated protein that endows its carrier with (lipo-)lactonase-dependent antioxidative features. Low levels of PON1 activity have been observed in association with obesity, a major risk factor for cardiovascular disease (CVD). Considering the well-recognized atheroprotective role of PON1, exogenous/endogenous factors that might modulate its levels/activity are raising great interest. Since adipokines represent a molecular link between obesity and CVD, we here explored the possible impact of these substances on PON1 activity/expression. The levels of interleukin (IL)-6, IL-8, tumor necrosis factor alpha, monocyte chemoattractant protein-1, hepatocyte growth factor, resistin, leptin, and adiponectin were measured along with arylesterase, paraoxonase, and lactonase activities of PON1 in 107 postmenopausal women. Moreover, the direct effect of resistin on PON1 expression was evaluated in vitro. Multivariate analysis revealed that only resistin was significantly and inversely correlated with PON1-lactonase activities (r = −0.346, p < 0.001) regardless of confounding factors such as age or HDL-cholesterol. It is worth noting that no statistical link was found between adipokine and arylesterase or paraoxonase, the two promiscuous activities of PON1. Notably, resistin down-regulated PON1 expression occurred in hepatocellular carcinoma cultures. Our study suggests that resistin might be a negative modulator of PON1 expression and anti-oxidative activity. View Full-Text
Keywords: oxinflammation; paraoxonase 1 (PON1); adipokines; resistin; postmenopausal woman oxinflammation; paraoxonase 1 (PON1); adipokines; resistin; postmenopausal woman
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MDPI and ACS Style

Tisato, V.; Romani, A.; Tavanti, E.; Melloni, E.; Milani, D.; Bonaccorsi, G.; Sanz, J.M.; Gemmati, D.; Passaro, A.; Cervellati, C. Crosstalk Between Adipokines and Paraoxonase 1: A New Potential Axis Linking Oxidative Stress and Inflammation. Antioxidants 2019, 8, 287.

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