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Open AccessArticle

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

1
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
2
Laboratory of Experimental Hepatology and Drug Targeting, IBSAL, CIBERehd, University of Salamanca, 37007 Salamanca, Spain
3
Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal
4
Department of Chemistry & CESAM&ECOMARE, University of Aveiro, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(8), 267; https://doi.org/10.3390/antiox8080267
Received: 24 June 2019 / Revised: 26 July 2019 / Accepted: 30 July 2019 / Published: 2 August 2019
(This article belongs to the Special Issue Phenolic Profiling and Antioxidant Capacity in Plants)
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Abstract

The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro. L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect. View Full-Text
Keywords: Mentha; Lavandula; Leonurus; liver diseases; HepG2 cells; antioxidant; phenolic compounds; UHPLC-DAD-ESI-MSn Mentha; Lavandula; Leonurus; liver diseases; HepG2 cells; antioxidant; phenolic compounds; UHPLC-DAD-ESI-MSn
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Pereira, O.R.; Macias, R.I.R.; Domingues, M.R.M.; Marin, J.J.G.; Cardoso, S.M. Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.. Antioxidants 2019, 8, 267.

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