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Medical and Dietary Uses of N-Acetylcysteine

Center for human molecular genetics and pharmacogenomics, Faculty of Medicine, University of Maribor, SI-2000 Maribor, Slovenia
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia
University of Ljubljana, Faculty of Health Sciences, Laboratory of Oxidative Stress Research, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(5), 111;
Received: 8 March 2019 / Revised: 9 April 2019 / Accepted: 23 April 2019 / Published: 28 April 2019
N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings. There are numerous other uses or proposed uses in medicine that are still in preclinical and clinical investigations. NAC is also used in food supplements and cosmetics. Despite its abundant use, there are projections that the NAC global market will grow in the next five years; therefore, the purpose of this work is to provide a balanced view of further uses of NAC as a dietary supplement. Although NAC is considered a safe substance, the results among clinical trials are sometimes controversial or incomplete, like for many other antioxidants. More clinical trials are underway that will improve our understanding of NAC applicability. View Full-Text
Keywords: N-acetylcysteine; acetylcysteine; pharmacology; physiology; dietary supplements; aging; sports N-acetylcysteine; acetylcysteine; pharmacology; physiology; dietary supplements; aging; sports
MDPI and ACS Style

Šalamon, Š.; Kramar, B.; Marolt, T.P.; Poljšak, B.; Milisav, I. Medical and Dietary Uses of N-Acetylcysteine. Antioxidants 2019, 8, 111.

AMA Style

Šalamon Š, Kramar B, Marolt TP, Poljšak B, Milisav I. Medical and Dietary Uses of N-Acetylcysteine. Antioxidants. 2019; 8(5):111.

Chicago/Turabian Style

Šalamon, Špela, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, and Irina Milisav. 2019. "Medical and Dietary Uses of N-Acetylcysteine" Antioxidants 8, no. 5: 111.

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