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The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

1
Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK
2
Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
3
Laboratory of Pharmacology, Unit of Clinical Pharmacology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
4
Second Department of Surgery, Democritus University of Thrace, 68100 Alexandroupolis, Greece
5
Redox Biology Centre, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
6
School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA
7
Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece
8
The Watrercress Company/The Wasabi Company, Waddock, Dorchester, Dorset DT2 8QY, UK
9
Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(4), 106; https://doi.org/10.3390/antiox8040106
Received: 4 February 2019 / Revised: 3 April 2019 / Accepted: 12 April 2019 / Published: 18 April 2019
(This article belongs to the Special Issue Natural Products in Health Promotion and Disease Prevention)
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Abstract

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies. View Full-Text
Keywords: isothiocyanates; glucosinolates; chemo-therapy; cruciferous vegetables; skin cancer; malignant melanoma; cell cycle; growth arrest isothiocyanates; glucosinolates; chemo-therapy; cruciferous vegetables; skin cancer; malignant melanoma; cell cycle; growth arrest
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Mitsiogianni, M.; Koutsidis, G.; Mavroudis, N.; Trafalis, D.T.; Botaitis, S.; Franco, R.; Zoumpourlis, V.; Amery, T.; Galanis, A.; Pappa, A.; Panayiotidis, M.I. The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents. Antioxidants 2019, 8, 106.

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