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Mutual Influences between Nitric Oxide and Paraoxonase 1

Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C/ Ramón y Cajal s/n, Alfara del Patriarca, 46115 Valencia, Spain
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés s/n, Burjassot, 46100 València, Spain
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(12), 619;
Received: 10 September 2019 / Revised: 2 December 2019 / Accepted: 3 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Paraoxonase in Oxidation and Inflammation)
One of the best consolidated paradigms in vascular pharmacology is that an uncontrolled excess of oxidizing chemical species causes tissue damage and loss of function in the endothelial and subendothelial layers. The fact that high-density lipoproteins play an important role in preventing such an imbalance is integrated into that concept, for which the expression and activity of paraoxonases is certainly crucial. The term paraoxonase (aryldialkyl phosphatase, EC encompasses at least three distinct isoforms, with a wide variation in substrate affinity, cell and fluid localization, and biased expression of polymorphism. The purpose of this review is to determine the interactions that paraoxonase 1 has with nitric oxide synthase, its reaction product, nitric oxide (nitrogen monoxide, NO), and its derived reactive species generated in an oxidative medium, with a special focus on its pathological implications. View Full-Text
Keywords: antioxidant; nitric oxide; paraoxonase; reactive oxygen species; serum lipoprotein; vascular inflammation antioxidant; nitric oxide; paraoxonase; reactive oxygen species; serum lipoprotein; vascular inflammation
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MDPI and ACS Style

Marín, M.; Moya, C.; Máñez, S. Mutual Influences between Nitric Oxide and Paraoxonase 1. Antioxidants 2019, 8, 619.

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