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Antioxidants 2018, 7(8), 106; https://doi.org/10.3390/antiox7080106

Redox Biology of Right-Sided Heart Failure

Department of Pharmacology and Physiology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
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Received: 25 June 2018 / Revised: 21 July 2018 / Accepted: 7 August 2018 / Published: 8 August 2018
(This article belongs to the Special Issue Novel Aspects of Redox and Antioxidant Signaling)
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Abstract

Right-sided heart failure is the major cause of death among patients who suffer from various forms of pulmonary hypertension and congenital heart disease. The right ventricle (RV) and left ventricle (LV) originate from different progenitor cells and function against very different blood pressures. However, differences between the RV and LV formed after birth have not been well defined. Work from our laboratory and others has accumulated evidence that redox signaling, oxidative stress and antioxidant regulation are important components that define the RV/LV differences. The present article summarizes the progress in understanding the roles of redox biology in the RV chamber-specificity. Understanding the mechanisms of RV/LV differences should help develop selective therapeutic strategies to help patients who are susceptible to and suffering from right-sided heart failure. Modulations of redox biology may provide effective therapeutic avenues for these conditions. View Full-Text
Keywords: antioxidants; redox; reactive oxygen species; right heart failure antioxidants; redox; reactive oxygen species; right heart failure
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Shults, N.V.; Melnyk, O.; Suzuki, D.I.; Suzuki, Y.J. Redox Biology of Right-Sided Heart Failure. Antioxidants 2018, 7, 106.

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