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Review

Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing

1
Plasma Life Science, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany
2
ZIK-PRE, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(10), 146; https://doi.org/10.3390/antiox7100146
Received: 28 September 2018 / Revised: 12 October 2018 / Accepted: 18 October 2018 / Published: 19 October 2018
(This article belongs to the Special Issue Nrf2 in Dermatological Pathologies)
Chronic wounds and ulcers are major public health threats. Being a substantial burden for patients and health care systems alike, better understanding of wound pathophysiology and new avenues in the therapy of chronic wounds are urgently needed. Cold physical plasmas are particularly effective in promoting wound closure, irrespective of its etiology. These partially ionized gases deliver a therapeutic cocktail of reactive oxygen and nitrogen species safely at body temperature and without genotoxic side effects. This field of plasma medicine reanimates the idea of redox repair in physiological healing. This review compiles previous findings of plasma effects in wound healing. It discusses new links between plasma treatment of cells and tissues, and the perception and intracellular translation of plasma-derived reactive species via redox signaling pathways. Specifically, (i) molecular switches governing redox-mediated tissue response; (ii) the activation of the nuclear E2-related factor (Nrf2) signaling, together with antioxidative and immunomodulatory responses; and (iii) the stabilization of the scaffolding function and actin network in dermal fibroblasts are emphasized in the light of wound healing. View Full-Text
Keywords: Keap1; kINPen; plasma medicine; reactive oxygen species (ROS); reactive nitrogen species (RNS); redox regulation Keap1; kINPen; plasma medicine; reactive oxygen species (ROS); reactive nitrogen species (RNS); redox regulation
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MDPI and ACS Style

Schmidt, A.; Bekeschus, S. Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing. Antioxidants 2018, 7, 146. https://doi.org/10.3390/antiox7100146

AMA Style

Schmidt A, Bekeschus S. Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing. Antioxidants. 2018; 7(10):146. https://doi.org/10.3390/antiox7100146

Chicago/Turabian Style

Schmidt, Anke, and Sander Bekeschus. 2018. "Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing" Antioxidants 7, no. 10: 146. https://doi.org/10.3390/antiox7100146

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