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A Disturbance in the Force: Cellular Stress Sensing by the Mitochondrial Network

1
Departments of Biology, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA
2
Clinical Laboratory Sciences, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA
Antioxidants 2018, 7(10), 126; https://doi.org/10.3390/antiox7100126
Received: 23 July 2018 / Revised: 13 September 2018 / Accepted: 17 September 2018 / Published: 22 September 2018
(This article belongs to the Special Issue Mitochondrial Function in Health and Disease)
As a highly dynamic organellar network, mitochondria are maintained as an organellar network by delicately balancing fission and fusion pathways. This homeostatic balance of organellar dynamics is increasingly revealed to play an integral role in sensing cellular stress stimuli. Mitochondrial fission/fusion balance is highly sensitive to perturbations such as loss of bioenergetic function, oxidative stress, and other stimuli, with mechanistic contribution to subsequent cell-wide cascades including inflammation, autophagy, and apoptosis. The overlapping activity with m-AAA protease 1 (OMA1) metallopeptidase, a stress-sensitive modulator of mitochondrial fusion, and dynamin-related protein 1 (DRP1), a regulator of mitochondrial fission, are key factors that shape mitochondrial dynamics in response to various stimuli. As such, OMA1 and DRP1 are critical factors that mediate mitochondrial roles in cellular stress-response signaling. Here, we explore the current understanding and emerging questions in the role of mitochondrial dynamics in sensing cellular stress as a dynamic, responsive organellar network. View Full-Text
Keywords: mitochondria; fusion; fission; OMA1; DRP; OPA1; stress; inflammation; cytokines; oxidative; bioenergetics mitochondria; fusion; fission; OMA1; DRP; OPA1; stress; inflammation; cytokines; oxidative; bioenergetics
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Gilkerson, R. A Disturbance in the Force: Cellular Stress Sensing by the Mitochondrial Network. Antioxidants 2018, 7, 126.

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