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Antioxidants
Volume 13
Issue 4
10.3390/antiox13040439
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Systematic Review

Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies

by
Karla Krislane Alves Costa Monteiro
1,*,
Marcos Eiji Shiroma
1,
Luciana Lamarão Damous
1,
Manuel de Jesus Simões
1,
Ricardo dos Santos Simões
1,
José Cipolla-Neto
2,
Edmund Chada Baracat
1 and
Jose Maria Soares-Jr.
1
1
Laboratório de Ginecologia Estrutural e Molecular (LIM-58), Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas HC-FMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil
2
Laboratório de Neurobiologia, Departamento de Fisiologia, Instituto de Ciências Médicas (ICB-I), Universidade de São Paulo, São Paulo 05508-000, Brazil
*
Author to whom correspondence should be addressed.
Antioxidants 2024, 13(4), 439; https://doi.org/10.3390/antiox13040439
Submission received: 22 January 2024 / Revised: 21 March 2024 / Accepted: 22 March 2024 / Published: 7 April 2024
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Abstract

Melatonin is an indoleamine with crucial antioxidant properties that are used to combat inflammatory and neoplastic processes, as well as control transplants. However, the clinical applications of melatonin have not yet been fully consolidated in the literature and require in-depth analysis. Objectives: This study reviewed the literature on the antioxidant properties of melatonin in rat models. Methods: We followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses and used the PubMed, LILACS, and Cochrane databases, Google Scholar, and article references, irrespective of publication time. Results: Ten articles involving 485 rats were selected, and the effects of melatonin on antioxidant markers were investigated. Melatonin increased superoxide dismutase in nine studies, glutathione peroxidase in seven studies, and catalase in five studies. In contrast, melatonin reduced glutathione in three studies and malonaldehyde in seven of eight studies. Conclusion: Our findings suggest that melatonin effectively reduces oxidative stress.
Keywords: melatonin; antioxidant; oxidative stress; nitrosative stress; superoxide dismutase melatonin; antioxidant; oxidative stress; nitrosative stress; superoxide dismutase

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MDPI and ACS Style

Monteiro, K.K.A.C.; Shiroma, M.E.; Damous, L.L.; Simões, M.d.J.; Simões, R.d.S.; Cipolla-Neto, J.; Baracat, E.C.; Soares-Jr., J.M. Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies. Antioxidants 2024, 13, 439. https://doi.org/10.3390/antiox13040439

AMA Style

Monteiro KKAC, Shiroma ME, Damous LL, Simões MdJ, Simões RdS, Cipolla-Neto J, Baracat EC, Soares-Jr. JM. Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies. Antioxidants. 2024; 13(4):439. https://doi.org/10.3390/antiox13040439

Chicago/Turabian Style

Monteiro, Karla Krislane Alves Costa, Marcos Eiji Shiroma, Luciana Lamarão Damous, Manuel de Jesus Simões, Ricardo dos Santos Simões, José Cipolla-Neto, Edmund Chada Baracat, and Jose Maria Soares-Jr. 2024. "Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies" Antioxidants 13, no. 4: 439. https://doi.org/10.3390/antiox13040439

APA Style

Monteiro, K. K. A. C., Shiroma, M. E., Damous, L. L., Simões, M. d. J., Simões, R. d. S., Cipolla-Neto, J., Baracat, E. C., & Soares-Jr., J. M. (2024). Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies. Antioxidants, 13(4), 439. https://doi.org/10.3390/antiox13040439

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