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Antioxidants
Volume 12
Issue 2
10.3390/antiox12020344
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Article

Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage

by
Elisabetta Marini
1,
Barbara Rolando
1,
Federica Sodano
1,2,
Federica Blua
1,
Giulia Concina
3,
Stefano Guglielmo
1,
Loretta Lazzarato
1 and
Konstantin Chegaev
1,*
1
Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy
2
Department of Pharmacy, “Federico II” University of Naples, 80131 Naples, Italy
3
Rita Levi-Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2023, 12(2), 344; https://doi.org/10.3390/antiox12020344
Submission received: 18 January 2023 / Revised: 25 January 2023 / Accepted: 30 January 2023 / Published: 1 February 2023
(This article belongs to the Special Issue Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies)
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Abstract

In the last years, research proofs have confirmed that hydrogen sulfide (H2S) plays an important role in various physio-pathological processes, such as oxidation, inflammation, neurophysiology, and cardiovascular protection; in particular, the protective effects of H2S in cardiovascular diseases were demonstrated. The interest in H2S-donating molecules as tools for biological and pharmacological studies has grown, together with the understanding of H2S importance. Here we performed a comparative study of a series of H2S donor molecules with different chemical scaffolds and H2S release mechanisms. The compounds were tested in human serum for their stability and ability to generate H2S. Their vasorelaxant properties were studied on rat aorta strips, and the capacity of the selected compounds to protect NO-dependent endothelium reactivity in an acute oxidative stress model was tested. H2S donors showed different H2S-releasing kinetic and produced amounts and vasodilating profiles; in particular, compound 6 was able to attenuate the dysfunction of relaxation induced by pyrogallol exposure, showing endothelial protective effects. These results may represent a useful basis for the rational development of promising H2S-releasing agents also conjugated with other pharmacophores.
Keywords: hydrogen sulfide; hydrogen sulfide-donors; vasodilation; pyrogallol; superoxide anion; oxidative stress; vascular endothelium hydrogen sulfide; hydrogen sulfide-donors; vasodilation; pyrogallol; superoxide anion; oxidative stress; vascular endothelium

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MDPI and ACS Style

Marini, E.; Rolando, B.; Sodano, F.; Blua, F.; Concina, G.; Guglielmo, S.; Lazzarato, L.; Chegaev, K. Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage. Antioxidants 2023, 12, 344. https://doi.org/10.3390/antiox12020344

AMA Style

Marini E, Rolando B, Sodano F, Blua F, Concina G, Guglielmo S, Lazzarato L, Chegaev K. Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage. Antioxidants. 2023; 12(2):344. https://doi.org/10.3390/antiox12020344

Chicago/Turabian Style

Marini, Elisabetta, Barbara Rolando, Federica Sodano, Federica Blua, Giulia Concina, Stefano Guglielmo, Loretta Lazzarato, and Konstantin Chegaev. 2023. "Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage" Antioxidants 12, no. 2: 344. https://doi.org/10.3390/antiox12020344

APA Style

Marini, E., Rolando, B., Sodano, F., Blua, F., Concina, G., Guglielmo, S., Lazzarato, L., & Chegaev, K. (2023). Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage. Antioxidants, 12(2), 344. https://doi.org/10.3390/antiox12020344

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