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Antioxidants
Volume 12
Issue 2
10.3390/antiox12020219
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Communication

Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry

by
Laura Serventi
1,
Giancarlo Angeles Flores
1,2,
Gaia Cusumano
1,
Davide Barbaro
1,
Bruno Tirillini
3,
Roberto Venanzoni
1,
Paola Angelini
1,*,
Alessandra Acquaviva
2,
Simonetta Cristina Di Simone
2,
Giustino Orlando
2,
Gokhan Zengin
4,
Luigi Menghini
2,* and
Claudio Ferrante
2
1
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, Italy
2
Botanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy
3
Department of Biomolecular Sciences, University of Urbino, 61029 Urbino, Italy
4
Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey
*
Authors to whom correspondence should be addressed.
Antioxidants 2023, 12(2), 219; https://doi.org/10.3390/antiox12020219
Submission received: 15 December 2022 / Revised: 30 December 2022 / Accepted: 15 January 2023 / Published: 18 January 2023
(This article belongs to the Special Issue Antioxidant Potential of Extracts from Foods and Plants)
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Abstract

Cannabis sativa products have historically been used for healing purposes; now their biological properties are supported with scientific evidence, but modern research has not yet fully developed its therapeutic potential. This study focuses on the cultivar of C. sativa called strawberry to understand the biological and medical potentials of hydroalcoholic extracts from two different parts of the plant: leaves and inflorescences. Two biological assets were investigated including antioxidant and antimicrobial potential. Additionally, quantitative determination of phenolic and terpenophenol compounds was conducted. The antimicrobial action was highlighted for the hydroalcoholic extract from inflorescences, especially against Escherichia coli and Bacillus subtilis. Among the dermatophytes’ strains, the most sensitive was Arthroderma currey. These effects could be related albeit partially to the pattern of the phenolics detected, among which the most prominent one was benzoic acid. On the other hand, antioxidant and antimicrobial effects of the extracts could be also mediated by the main terpenophenolics identified and quantified, namely cannabidiolic acid and cannabidiol. Collectively, the present data point to the potential use of the inflorescences from the C. sativa cultivar strawberry as a valuable plant material for the development of bioactive extracts with antioxidant and antimicrobial effects
Keywords: Cannabis sativa; antimicrobial; antioxidant; phenolic compounds; benzoic acid; cannabidiol; cannabidiolic acid Cannabis sativa; antimicrobial; antioxidant; phenolic compounds; benzoic acid; cannabidiol; cannabidiolic acid

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MDPI and ACS Style

Serventi, L.; Flores, G.A.; Cusumano, G.; Barbaro, D.; Tirillini, B.; Venanzoni, R.; Angelini, P.; Acquaviva, A.; Di Simone, S.C.; Orlando, G.; et al. Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry. Antioxidants 2023, 12, 219. https://doi.org/10.3390/antiox12020219

AMA Style

Serventi L, Flores GA, Cusumano G, Barbaro D, Tirillini B, Venanzoni R, Angelini P, Acquaviva A, Di Simone SC, Orlando G, et al. Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry. Antioxidants. 2023; 12(2):219. https://doi.org/10.3390/antiox12020219

Chicago/Turabian Style

Serventi, Laura, Giancarlo Angeles Flores, Gaia Cusumano, Davide Barbaro, Bruno Tirillini, Roberto Venanzoni, Paola Angelini, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, and et al. 2023. "Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry" Antioxidants 12, no. 2: 219. https://doi.org/10.3390/antiox12020219

APA Style

Serventi, L., Flores, G. A., Cusumano, G., Barbaro, D., Tirillini, B., Venanzoni, R., Angelini, P., Acquaviva, A., Di Simone, S. C., Orlando, G., Zengin, G., Menghini, L., & Ferrante, C. (2023). Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry. Antioxidants, 12(2), 219. https://doi.org/10.3390/antiox12020219

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